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β-NaGdF4:Eu3+ nanocrystal markers for melanoma tumor imaging

机译：β-NagdF4：黑色素瘤肿瘤成像的Eu3 +纳米晶体标志物

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In the current paper, the strategy of tuning the optical and structural properties of Eu doped nanocrystals (NCs) is described with the emphasis on obtaining NCs with high brightness and photostability at the desired excitation and emission range. Those NCs are further chemically functionalized and covalently conjugated with lectins, providing specific (but reversible) targeting of pathological glycans on the surface of melanoma cells. Nanoconjugates are then injected intravenously into the blood stream of laboratory mice. Subsequently, histological slices were examined by fluorescence microscopy, whereas whole melanoma tumor were examined by ex vivo fluorescence imaging. Analysis revealed specific targeting, high intensity and photostability of the signal during visualization.
机译：在目前的纸张中，调节EU掺杂纳米晶体（NCS）的光学和结构性质的策略描述，重点在所需的激发和发射范围处获得具有高亮度和光稳定性的NC。那些NCS进一步化学官能化并与章节共价缀合，提供了对黑色素瘤细胞表面的病理聚糖的特异性（但可逆）靶向。然后将纳米缀合物静脉内注射到实验室小鼠的血流中。随后，通过荧光显微镜检查组织学切片，而通过离体荧光成像检查全黑色素瘤肿瘤。分析显示在可视化期间信号的特定靶向，高强度和光安全性。

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