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Fabrication of AIE-active amphiphilic fluorescent polymeric nanoparticles through host–guest interaction

机译：通过宿主 - 访客互动制备AIE-活性两亲荧光聚合物纳米粒子

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Fluorescent polymeric nanoparticles (FPNs) have obtained more and more attention in recent years due to their excellent performance in the fields of bioimaging, biosensing, theranostics and many other biomedical applications. In this work, we reported a novel method to fabricate amphiphilic fluorescent copolymers through host–guest interactions based on an aggregation-induced emission (AIE) active dye (named as Ad-PhNH _(2) ) and β cyclodextrin (β-CD) contained polymers, which were synthesized by free radical polymerization and subsequent ring-opening reaction. These AIE active copolymers can self assemble into FPNs (named as PEGMA–IA–β-CD/Ad-PhNH _(2) ) due to their amphiphilic properties. The hydrophobic dye was aggregated in the core and therefore can emit strong fluorescent intensity due to its AIE feature. However, the hydrophilic polymers that covered the hydrophobic core can endow good dispersibility in pure aqueous solution. Biological evaluation results demonstrated that PEGMA–IA–β-CD/Ad-PhNH _(2) FPNs can be effectively internalized into cells and they have shown low cytotoxicity. More importantly, the molar ratio of β-CD to Ad-PhNH _(2) can be facilely adjusted and the surplus β-CD can be used for carrying chemical anticancer agents. Furthermore, a large number of carboxyl groups were generated during the ring opening reaction. These negative carboxyl groups can be potentially used for further conjugation reactions and for biological delivery. The above described features of PEGMA–IA–β-CD/Ad-PhNH _(2) FPNs make them a prospect in biological imaging and delivery applications.
机译：近年来，近年来，荧光聚合物纳米颗粒（FPNS）由于其在生物分析，生物传感，治疗器和许多其他生物医学应用领域的优异性能而获得了越来越多的关注。在这项工作中，我们报道了一种通过基于聚集诱导的发射（AIE）活性染料（命名为Ad-PhNH _（2））和β环糊精（β-CD）的宿主 - 客体相互作用来制造两亲荧光共聚物的新方法含有的聚合物，其通过自由基聚合和随后的开环反应合成。由于其两亲性质，这些AIE活性共聚物可以自组装成FPNS（命名为PEGMA-IA-β-CD / AD-PHNH _（2））。疏水染料在核心中聚集，因此由于其AIE特征，可以发出强烈的荧光强度。然而，覆盖疏水芯的亲水聚合物可以在纯水溶液中赋予良好的分散性。生物学评价结果表明，PEGMA-IA-β-CD / AD-PHNH _（2）FPN可以有效地内化到细胞中，并且它们显示出低细胞毒性。更重要的是，可以易于调节β-Cd至Ad-PhNH _（2）的摩尔比，并且剩余β-CD可用于携带化学抗癌剂。此外，在开环反应期间产生大量的羧基。这些负羧基可以潜在地用于进一步的缀合反应和生物递送。上述PEGMA-IA-β-CD / AD-PHNH _（2）FPN的特征使它们成为生物成像和递送应用的前景。

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