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Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization

机译:纳米抗酸剂增强了散装同伴的pH中和:合成和表征

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Antacids are crucial in the treatment of gastro-esophageal reflux disease and peptic ulcers. Antacids based on the calcite phase of bulk calcium carbonate have been the standard for over fifty years. More recent research has shown that nanomaterial forms of such bulk materials often have improved properties. However, the metastable vaterite form of calcium carbonate is particularly difficult to synthesize as a nanomaterial, and thus has not been extensively studied. Here, we describe the synthesis of these particles and investigate them for antacid applications. Experimental and computational approaches show that nanoscale vaterite particles maintain neutral gastric pH values three times longer than commercial antacids.
机译:抗酸剂在治疗胃食管反流疾病和消化溃疡方面至关重要。基于批量碳酸钙的方解石阶段的抗酸性是五十年的标准。最近的研究表明,这种散装材料的纳米材料通常具有改善的性能。然而,碳酸钙的亚碳酸钙形式尤其难以合成为纳米材料,因此尚未被广泛研究。在这里,我们描述了这些颗粒的合成并研究了抗酸应用。实验和计算方法表明,纳米级Vaterite颗粒比商业抗酸剂长3倍的中性胃pH值。

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