Construction and drug delivery of a fluorescent TPE-bridged cyclodextrin/hyaluronic acid supramolecular assembly

Qian Zhao; Yong Chen; Mo Sun; Xian-Jing Wu; Yu Liu

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Construction and drug delivery of a fluorescent TPE-bridged cyclodextrin/hyaluronic acid supramolecular assembly

机译：荧光TPE桥接环糊精/透明质酸超分子组装的构建和药物递送

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A supramolecular assembly was successfully constructed from tetraphenylethylene-bridged β-cyclodextrin tetramers (TPECD) and adamantyl-grafted hyaluronic acids (HAAD) and fully characterized by UV-vis spectroscopy, fluorescence emission spectroscopy, zeta potential, SEM, AFM and TEM. The obtained TPECD–HAAD assembly, which existed as spherical nanoparticles with an average diameter of 50 nm, emitted stronger fluorescence than free TPECD due to the restricted intramolecular rotation. Significantly, this supramolecular assembly can efficiently load the anticancer drug doxorubicin (DOX) into cancer cells, and the resultant DOX@TPECD–HAAD system had higher anticancer ability and fewer side effects than free DOX.

机译：通过四苯基己烯桥β-环糊精四聚体（TPECD）和亚氨基乙基接枝透明质酸（HAAD）成功构建了超分子组件，并用UV-Vis光谱，荧光发射光谱，Zeta电位，SEM，AFM和TEM完全表征。所获得的TPECD-HAAD组件，其作为平均直径为50nm的球形纳米颗粒，由于限制的分子内旋转而比游离TPECD发出更强的荧光。值得注意的是，这种超分子组件可以有效地将抗癌药物Doxorubicin（DOX）载入癌细胞，并且所得DOX @TPECD-HAAD系统具有更高的抗癌能力和比自由DOX更少的副作用。

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《RSC Advances》 |2016年第56期|共7页
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Qian Zhao; Yong Chen; Mo Sun; Xian-Jing Wu; Yu Liu;
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1. Construction and drug delivery of a fluorescent TPE-bridged cyclodextrin/hyaluronic acid supramolecular assembly [J] . Zhao Qian, Chen Yong, Sun Mo, RSC Advances . 2016,第56期

机译：荧光TPE桥联的环糊精/透明质酸超分子组装体的构建和药物递送
2. beta-Cyclodextrin-modified hyaluronic acid-based supramolecular self-assemblies for pH- and esterase-dual-responsive drug delivery [J] . Bai Yang, Liu Cai-Ping, Chen Di, Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides . 2020,第1期

机译：β-环糊精改性的基于透明质酸的超分子自组装，用于pH-和酯酶 - 双响应药物递送
3. Facile construction of shape-regulated beta-cyclodextrin-based supramolecular self-assemblies for drug delivery [J] . Bai Yang, An Na, Chen Di, Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides . 2020,第期

机译：体形β-环糊精的超分子自组装的舒适构造用于药物递送
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机译：生物相容性α-环糊精/聚乙二醇自组装超分子纳米颗粒用于药物递送
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机译：β-环糊精超分子纳米颗粒的制备作为药物递送系统的设计，制备和性质。
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机译：层状介孔二氧化硅-透明质酸-环糊精双功能层压：荧光探针和主客体相互作用在药物输送领域中的应用研究
7. Hyaluronic Acid-Based Biocompatible Supramolecular Assembly for Sustained Release of Antiretroviral Drug [O] . Byeongwoon Song, István Puskás, Lajos Szente, 2016

机译：基于透明质酸的生物相容性超分子组件，用于持续释放抗逆转录病毒药物
8. Recent Advances in Supramolecular Assemblies with Nucleic Acids; Conference proceedings (abstracts only) [R] . Barthelemy, P. 2007

机译：核酸超分子组装的最新进展;会议论文集（仅限摘要）

Construction and drug delivery of a fluorescent TPE-bridged cyclodextrin/hyaluronic acid supramolecular assembly

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