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首页> 外文期刊>RSC Advances >Combined and individual doxorubicin/vancomycin drug loading, release kinetics and apatite formation for the CaO–CuO–P2O5–SiO2–B2O3 mesoporous glasses
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Combined and individual doxorubicin/vancomycin drug loading, release kinetics and apatite formation for the CaO–CuO–P2O5–SiO2–B2O3 mesoporous glasses

机译：联合和单独的多柔比霉素/万古霉素药物载荷，释放动力学和磷灰石形成用于CaO-CuO-P2O5-SiO2-B2O3中孔眼镜

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The novel mesoporous glass series based on (25 ? x )CaO– x CuO–10P _(2) O _(5) –5B _(2) O _(3) –60SiO _(2) ( x = 2.5, 5, 7.5, 10) has been prepared using the sol–gel technique. The pore size of the prepared mesoporous bioactive glasses (MBG) lies between 6.1 and 9.1 nm, whereas the surface area varies from 281 to 418 m ~(2) g ~(?1) . The pH variation, zeta potential, Fourier transform infra-red (FTIR) spectroscopy and simulated body fluid (SBF) studies indicated the in vitro bioactivity of all the MBGs. The MBGs were loaded with the anticancerous and antibacterial drugs, doxorubicin and vancomycin, respectively. The increasing copper content predominantly influenced the bioactive properties as well as the drug loading and release kinetics of the doxorubicin and vancomycin drugs. In addition to the individual loading of drugs in the MBG, both the drugs were also loaded together in the MBG to investigate the effect of combined loading on the release capability of the MBGs.
机译：基于（25≤x）CaO-x CuO-10p _（2）O _（5）-5b _（2）O _（3）-60sio _（2）（x = 2.5，5使用溶胶 - 凝胶技术制备7.5,10）。制备的中孔生物活性玻璃（MBG）的孔径位于6.1至9.1nm之间，而表面积从281变化到418m〜（2）g〜（α1）。 pH变异，Zeta电位，傅里叶变换红外线（FTIR）光谱和模拟体液（SBF）研究表明了所有MBG的体外生物活性。 MBG分别用抗癌和抗菌药物，多柔比星和万古霉素装载。铜含量的增加主要影响了生物活性特性以及多柔比蛋白和万古霉素药物的药物负载和释放动力学。除了在MBG中的单独加载药物外，还在MBG中也将两种药物一起装载，以研究组合负载对MBGS释放能力的影响。

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