Iron (Fe) was doped into the surface of pure titanium by iron plasma immersion ion implantation (Fe PIII), so that a nano-thick surface layer, composed of abundant reactive sites and capable of producing reactive oxygen species (ROS), was produced on the material. In vitro results demonstrated that the Fe PIII treated titanium was able to inhibit bacterial adhesion ( E. coli and P. aeruginosa ), but facilitate the adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 and/or rBMSCs. The antibacterial efficacy of Fe PIII groups is likely determined by both the intrinsic potential of the materials in ROS generation and the availability of electrons supplied by respiration electron transport chains (ETC) in bacterial cells, which is important to the cytocompatibility of the materials. This study revealed that doping of iron can modify the electrochemical behavior of titanium and regulate its potential on production of ROS, which controls the selective nature of biomaterials in toxicity.
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机译：通过铁等离子体浸渍离子注入（Fe PIII）掺杂铁（Fe）进入纯钛表面，使得由纳米厚的表面层组成，由丰富的反应性位点组成并能够产生活性氧（ROS），在材料上。体外结果表明，Fe PIII处理的钛能够抑制细菌粘附（大肠杆菌和铜绿假单胞菌），但促进MC3T3-E1和/或RBMSC的粘附性，增殖和成骨分化。 Fe PIII基团的抗菌效果可能通过ROS生成中材料的内在电位和由细菌细胞中的呼吸电子传输链（ETC）提供的电子的可用性来确定，这对材料的细胞相容性是重要的。本研究表明，铁的掺杂可以改变钛的电化学行为，并调节其对ROS的产生的潜力，这控制了毒性的生物材料的选择性本质。
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