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首页> 外文期刊>RSC Advances >Nanostructured surface of electrospun PCL/dECM fibres treated with oxygen plasma for tissue engineering
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Nanostructured surface of electrospun PCL/dECM fibres treated with oxygen plasma for tissue engineering

机译：用氧等离子体进行组织工程治疗的Electrom of Electrom of ElectromativeS的纤维表面

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Recently, various biomimetic scaffolds using a decellularised extracellular matrix (dECM) have been applied in tissue regeneration applications because dECM consists of highly bioactive fibrous proteins and polysaccharides. Here, to enhance the biofunctionality of the dECM surface, homogeneously roughened nanoscale patterns ( R _(a) = 524 ± 66 nm) on the surface of poly(ε-caprolactone) (PCL)-based dECM were developed by selecting optimal plasma treatment conditions (power: 15 W, oxygen flow rate: 5 standard cubic cm per min, and total plasma exposure time: 4 h). To determine its efficiency as a biomedical scaffold, the plasma-treated PCL/dECM was evaluated for various cellular activities, metabolic activity and osteogenic differentiation, and compared with two controls: plasma-treated pure PCL fibres and an untreated PCL/dECM fibrous structure. Significant increases in cell viability (>1.5-fold) and calcium mineralisation (>1.8-fold) were observed for the nanoscale-roughened PCL/dECM fibrous structure compared with the untreated PCL/dECM fibrous mat. Based on the results, we propose a new surface model of a surface-modified biomedical scaffold, which can significantly promote cell activities at the interface between cells and the surface to regenerate hard tissues.
机译：最近，使用脱细胞化细胞外基质（DECM）的各种仿生支架已在组织再生应用中应用，因为DECM由高度生物活性纤维蛋白和多糖组成。这里，通过选择最佳的等离子体处理，通过选择最佳的等离子体处理来增强DECM表面的生物官能（R _（A）= 524±66nm）的均匀性粗糙化纳米级图案（R _（a）= 524±66nm）条件（功率：15 W，氧气流速：5个标准立方厘米/分钟，总血浆暴露时间：4小时）。为了确定其作为生物医学支架的效率，评价各种细胞活性，代谢活性和成骨分化的等离子体处理的PCL / DECM，并与两种对照进行比较：血浆处理的纯PCL纤维和未处理的PCL / DECM纤维结构。与未处理的PCL / DECM纤维垫相比，对于纳米级 - 粗糙的PCL / DECM纤维结构，观察到细胞活力（> 1.5倍）和钙矿化（> 1.8倍）的显着增加。基于结果，我们提出了一种表面改性生物医学支架的新表面模型，其可以显着促进细胞与表面之间的界面处的细胞活性，以再生硬组织。

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