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首页> 外文期刊>RSC Advances >Phytochemical investigation, hypocholesterolemic and anti-atherosclerotic effects of Amaranthus viridis leaf extract in hypercholesterolemia-induced rabbits
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Phytochemical investigation, hypocholesterolemic and anti-atherosclerotic effects of Amaranthus viridis leaf extract in hypercholesterolemia-induced rabbits

机译：苋菜血液血液血症诱导兔苋属紫藤叶提取物的植物化学研究，脱粒咯咯醇和抗动脉粥样硬化作用

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Hypercholesterolemia is one of the main causes for coronary heart disease, which occurs due to high levels of serum cholesterol. Oxidized LDL accumulation leads to atherosclerotic plaque formation, which contributes to myocardial infarction and cardiovascular diseases. Consumption of statins leads to adverse health effects such as liver and muscle toxicity; thus attention is now focused on alternative treatments using chemicals of plant origin. This study is designed to investigate the phytochemical components, hypocholesterolemic and antiatherosclerotic effects of Amaranthus viridis ( A. viridis ) using hypercholesterolemic rabbits. Gas Chromatography Mass Spectrometry (GC-MS/MS) analysis revealed 30 compounds, while Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) detected the presence of ascorbic acid, rutin, quercetin and catechin. An animal model study was performed on twenty New Zealand white rabbits that were randomly divided into 5 groups and fed with normal diet, 2% high cholesterol diet (HCD), 2% HCD + 10 mg kg ~(?1) simvastatin, 2% HCD + 100 mg kg ~(?1) A. viridis extract and 2% HCD + 200 mg kg ~(?1) A. viridis extract, respectively. The supplementation with A. viridis extract significantly reduced total cholesterol, LDL and triglyceride levels, and increased the levels of HDL and antioxidant enzymes (SOD and GPx). The elevated levels of AST, ALT and creatine kinase indicate liver and muscle injuries. Treatment with A. viridis extract also diminished the development of aortic plaques and decreased the intima?:?media ratio, as observed in simvastatin-treated rabbits. The phytocomponents of A. viridis have been reported to have therapeutic effects in treating hypercholesterolemia and atherosclerosis, and the in vivo study on A. viridis further confirms its potential as an alternative therapeutic agent.
机译：高胆固醇血症是冠心病的主要原因之一，这是由于高水解的血清胆固醇发生。氧化的LDL累积导致动脉粥样硬化斑块形成，这有助于心肌梗死和心血管疾病。他汀类药物的消费导致肝脏和肌肉毒性等不利健康影响;因此，现在关注使用植物来源的化学物质的替代治疗方法。本研究旨在使用高胆固醇兔苋属viridis（A.Viridis）的植物化学成分，次粒细胞和抗炎作用。气相色谱质谱（GC-MS / MS）分析显示30种化合物，而反向相高性能液相色谱（RP-HPLC）检测到抗坏血酸，芦丁，槲皮素和儿茶素的存在。在二十个新西兰白兔上进行动物模型研究，随机分为5组，喂养正常饮食，2％高胆固醇饮食（HCD），2％HCD + 10mg kg〜（α1）辛伐他汀，2％ HCD + 100mg kg〜（α1）A. viridis提取物和2％HCD + 200mg kg〜（α1）A.Viridis提取物。 viridis提取物的补充显着降低了总胆固醇，LDL和甘油三酯水平，并增加了HDL和抗氧化酶的水平（SOD和GPX）。 AST，ALT和肌酸激酶的升高，表明肝脏和肌肉损伤。用A viridis提取物的治疗也降低了主动脉噬斑的发育并降低了内部的？：培养基比，如辛伐他汀治疗的兔所观察到。据报道，A.Viridis的植物组分在治疗过高胆固醇血症和动脉粥样硬化方面具有治疗效果，并且对A的体内研究进一步证实其作为替代治疗剂的潜力。

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