• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Intrinsically disordered proteins in PubMed: what can the tip of the iceberg tell us about what lies below?
【24h】

Intrinsically disordered proteins in PubMed: what can the tip of the iceberg tell us about what lies below?

机译：在pubmed中有本质上紊乱的蛋白质：冰山一角可以告诉我们什么谎言？

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Intrinsically disordered proteins (IDPs) have a troubled history in the literature. Historically, a wide variety of terminology has been used to describe these strange proteins that do not adopt a stable three-dimensional structure. We provide here a survey of the current status of both IDPs and IDP terminology in PubMed. We have performed an extensive search of the literature from 1978 through 2014 and compiled a list of 1127 proteins and protein domains and the corresponding citations that refer to these proteins using IDP terminology. We show that papers that use IDP terminology are only the tip of the iceberg in terms of the larger body of literature referring to this group of proteins. Furthermore, our analysis suggests that this is likely due to a lack of perceived relevance rather than a lack of awareness. Finally, we have analyzed the language provided by author keywords, MeSH terms, and abstracts as well as the journals that are currently publishing IDP articles. Our results demonstrate a convergence on a common set of terminology and a rise in the number of papers using this terminology. However, our results also demonstrate that we have not reached the point where IDP terminology is fully accepted and embraced in the literature.
机译：本质上紊乱的蛋白质（IDP）在文献中具有困扰的历史。从历史上看，使用各种术语用于描述这些不采用稳定的三维结构的奇怪蛋白质。我们在这里提供了对PubMed中的IDP和IDP术语的当前状态的调查。我们从1978年到2014年对文献进行了广泛的搜索，并编制了1127个蛋白质和蛋白质结构域的列表以及使用IDP术语参考这些蛋白质的相应引文。我们展示了使用IDP术语的论文仅是冰山的尖端，从较大的文献中指的是这组蛋白质。此外，我们的分析表明，这可能是由于缺乏感知相关性而不是缺乏意识。最后，我们分析了作者关键字，网格术语和摘要提供的语言以及当前发布IDP文章的期刊。我们的结果表明，使用本术语的普通术术语和增加的纸张数量的融合。但是，我们的结果也表明我们尚未达到IDP术语在文献中完全被接受并拥有的地步。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号