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首页> 外文期刊>RSC Advances >Lipase-catalyzed synthesis of oxidation-responsive poly(ethylene glycol)-b-poly(β-thioether ester) amphiphilic block copolymers
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Lipase-catalyzed synthesis of oxidation-responsive poly(ethylene glycol)-b-poly(β-thioether ester) amphiphilic block copolymers

机译：脂肪酶催化合成的氧化响应聚（乙二醇）-B-聚（β-硫醚酯）两亲嵌段共聚物

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A series of novel oxidation-responsive amphiphilic diblock copolymers with β-thioether ester groups were synthesized via the one-step lipase-catalyzed polycondensation of methyl 3-((2-hydroxyethyl)thio)propanoate (MHETP) with monomethoxy poly(ethylene glycol) (mPEG) using immobilized lipase B from Candida antarctica (CALB) as the catalyst. The amphiphilic poly(ethylene glycol)- b -poly(β-thioether ester) (mPEG- b -PTE) diblock copolymers could self-assemble to form nanosized micelles in aqueous solution with low critical micelle concentration (CMC). The micelles were able to undergo a H _(2) O _(2) -triggered disassembly due to the oxidizable thioether groups and degradable ester groups in the hydrophobic PTE core. The oxidation-responsive behaviour of the micelles was further investigated by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Nile Red, a hydrophobic model drug, was encapsulated into the polymeric micelles and showed fast release upon the addition of H _(2) O _(2) . Cell cytotoxicity tests indicated that the micelles had low cytotoxicity toward HeLa cells. The oxidation-insensitive poly(ethylene glycol)- b -poly(ε-caprolactone) (mPEG- b -PCL) diblock copolymer was also prepared for comparison. All these findings demonstrated the potential of mPEG- b -PTE diblock copolymers as a promising oxidation-responsive nanocarrier for controlled drug delivery.
机译：通过用单甲氧基聚（MHETP）的一步脂肪酶催化的缩聚（MHETP）通过单甲氧基聚（乙二醇），通过单步脂肪酶催化的缩聚合成具有β-硫醚酯基的一系列新的氧化响应式两亲二嵌段共聚物。 （MPEG）使用来自Candida抗野胶（CALB）的固定化脂肪酶B作为催化剂。两亲性聚（乙二醇） - B-聚（β-硫醚酯）（MPEG-B -PTE）二嵌段共聚物可以自组装成在具有低临界胶束浓度（CMC）的水溶液中形成纳米粒子化胶束。由于疏水性硫醚基团和疏水性PTE核中的可降解酯基，胶束能够经历H _（2）O _（2） - 触发拆卸。通过动态光散射（DLS）和透射电子显微镜（TEM）进一步研究胶束的氧化响应性能。尼罗红，一种疏水模型药物被包封成聚合物胶束，并在加入H _（2）O _（2）时显示快速释放。细胞细胞毒性试验表明胶束对HeLa细胞具有低细胞毒性。还制备氧化不敏感聚（乙二醇）-B -poly（ε-己内酯）（MPEG-B-PCL）二嵌段共聚物进行比较。所有这些发现证明了MPEG-B -PTE二嵌段共聚物的潜力作为受控药物递送的有前途的氧化响应纳米载体。

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