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首页> 外文期刊>RSC Advances >Branched polyethyleneimine modified with hyaluronic acid via a PEG spacer for targeted anticancer drug delivery
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Branched polyethyleneimine modified with hyaluronic acid via a PEG spacer for targeted anticancer drug delivery

机译：通过PEG间隔物改性分支聚乙烯亚胺，用于靶向抗癌药物递送

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It is generally required to develop a nanocarrier system that is able to improve the water solubility of an anticancer drug and enable targeted delivery of the drug to cancer cells via a receptor-mediated endocytosis pathway. In this work, polyethyleneimine (PEI) was sequentially modified with dual functional polyethylene glycol (NH _(2) –PEG–COOH), hyaluronic acid (HA), and fluorescein isothiocyanate (FI). The prepared PEI–FI–(PEG–HA) conjugate was then used as a nanoplatform to encapsulate the anticancer drug doxorubicin (DOX). We show that the formed PEI–FI–(PEG–HA) conjugate is able to encapsulate approximately 19 DOX molecules within each multifunctional PEI, and the formed PEI–FI–(PEG–HA)/DOX complexes can release DOX in a pH-dependent manner with a higher DOX release rate under an acidic pH condition than under a physiological pH condition. In addition, the PEI–FI–(PEG–HA)/DOX complexes are able to specifically target cancer cells overexpressing CD44 receptors as confirmed via flow cytometric analysis and confocal microscopic observation, and thus deliver DOX to the target cancer cells to inhibit their growth. The developed HA-targeted PEI may hold great promise to be used as an efficient nanoplatform for the targeted delivery of different anticancer drugs.
机译：通常需要开发一种能够通过受体介导的内吞作用途径来改善抗癌药物的纳米载体系统，并能够通过受体介导的内吞作用靶向药物靶向药物递送给癌细胞。在这项工作中，用双官能聚乙二醇（NH _（2）-PEG-COOH），透明质酸（HA）和荧光素异硫氰酸酯（FI）用双官能聚乙烯（PEI）依次改性聚乙烯亚胺（PEI）。然后将制备的PEI-FI-（PEG-HA）缀合物用作纳米孔，以包封抗癌药物DOOXORUBICIN（DOX）。我们表明所形成的PEI-（PEG-HA）缀合物能够在每个多功能PEI内包封大约19个DOX分子，并且形成的PEI-FI-（PEG-HA）/ DOX复合物可以在pH-中释放DOX在酸性pH条件下具有较高的Dox释放率的依赖性方式而不是在生理pH条件下。另外，PEI-FI-（PEG-HA）/ DOX复合物能够特异性地靶向过表达CD44受体的癌细胞，如通过流式细胞术分析和共聚焦显微镜观察确认，从而将DOX传递给靶癌细胞以抑制其生长。开发的HA目标PEI可能具有较高的希望被用作有针对性抗癌药物的有效递送的有效纳米片。

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