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Geometric effects of nano-hole arrays for label free bio-detection

机译：纳米孔阵列为标签自由生物检测的几何效果

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摘要

Geometric effects of nano-hole arrays were investigated for label free bio-detection. Because the nano-hole arrays were designed to present a filtered peak wavelength in the visible light region, filtered color changes caused by different biomolecules were easily observed with a microscope or even by the naked eye. Generally, many biomolecules are transparent or colorless in the visible range, so that it is hard to distinguish among them using visible observation. However, their molecular structure and composition induce some differences in the dielectric constant or refractive index causing a filtered color shift in the nano-hole array structure. Here, the contribution of geometric parameters such as the hole diameter and the spacing between nano-holes for bio-detection was evaluated to maximize the change in color among different biomolecules. A larger hole size and space between the holes enabled the biomolecules to be easily distinguished. Even if the change in color was not distinctive enough by eye in some cases, it was possible to distinguish the change by simple analysis of the ‘ Hue ’ values or by the ‘ Lab ’ color coordinates obtained from the photo images. Therefore, this technique can have high probability of realization for real-time detection of cells without the use of bio-markers.
机译：研究了纳米孔阵列的几何效果，用于标记免费生物检测。因为纳米孔阵列被设计为在可见光区域中呈现过滤的峰值波长，所以用显微镜甚至肉眼容易地观察由不同的生物分子引起的过滤的颜色变化。通常，许多生物分子在可见范围内是透明或无色的，因此难以使用可见观察来区分它们。然而，它们的分子结构和组成诱导介电常数或折射率的一些差异，导致纳米孔阵列结构中的过滤的颜色偏移。这里，评估几何参数的贡献，例如孔直径和纳米孔之间的间距进行生物检测，以最大化不同生物分子之间的颜色变化。孔之间的孔尺寸和空间使得能够容易地区分生物分子。即使在某些情况下，眼睛没有足够的颜色变化，也可以通过简单地分析从照片图像获得的“LAB”颜色坐标来区分变化。因此，该技术可以具有高概率的实现，以便在不使用生物标记的情况下实时检测细胞的实时检测。

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