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Development of a visible nanothermometer with a highly emissive 2′-O-methylated guanosine analogue

机译:具有高发光2'-O-甲基化鸟苷类模拟的可见纳米计的开发

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We have synthesized a fluorescent base analogue, 2-aminothieno[3,4- d ]pyrimidine based G-mimic deoxyribonucleoside, 2′-OMe- ~(th) G , and investigated its photophysical properties and DNA incorporation. The 2′ methoxy group of 2′-OMe- ~(th) G effectively induces the Z-form DNA. Finally we have constructed a visible nanothermometer based on the B–Z transition of DNA using 2′-OMe- ~(th) G .
机译:我们已经合成了荧光基础碱基,2-氨基噻吩[3,4- D]嘧啶的G-MIMIC脱氧核糖核苷,2'-ω-(Th)G,并研究了其光学性质和DNA掺入。 2'-Ome-〜(Th)G的2'甲氧基团有效地诱导Z形式DNA。最后,我们基于使用2'-OME-〜(Th)G基于DNA的B-Z转变的可见纳米计。

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