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首页> 外文期刊>RSC Advances >In vivo reversal of general anesthesia by cucurbit[7]uril with zebrafish models
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In vivo reversal of general anesthesia by cucurbit[7]uril with zebrafish models

机译：在葫芦中的全身麻醉的体内逆转[7]尿嘧啶与斑马鱼模型

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A general anesthetic is a drug that brings about a reversible loss of consciousness, during a surgical or therapeutic procedure to render the patient free of pain and anxiety. However, the effect of anesthetics may linger far beyond the necessary time required and induce adverse effects. In addition, many surgical patients need to recover to a conscious state that allows them to make important decisions soon after their surgery. Unfortunately, there are currently no clinically-available anti-dotes to reverse the effects of anesthetics. In this study, we demonstrate the in vitro supramolecular host–guest complexations between macrocyclic cucurbit[7]uril (CB[7]) and a commonly used general anesthetic in fish, tricaine mesylate (TM), and we report for the first time the in vivo reversal effect of CB[7] to general anesthesia induced by TM with zebrafish models. These findings might lead to a new approach that may allow patients to regain lucidity much faster than their natural recovery from general anesthesia, and may also be used to reverse potentially life-threatening toxic effects encountered by some patients in response to general anesthesia.
机译：一般麻醉剂是一种药物，它在手术或治疗程序期间带来可逆的意识丧失，以使患者没有痛苦和焦虑。然而，麻醉剂的效果可能丧失远远超出所需的必要时间并诱导不良反应。此外，许多手术患者需要恢复到一种有意识状态，让他们在手术后不久就会做出重要决策。不幸的是，目前没有临床上的抗托点来扭转麻醉剂的影响。在这项研究中，我们证明了宏环葫芦（CB [7]）与鱼类，三胞苷甲磺酸盐（TM）中常用的全身麻醉剂之间的体外超分子宿主 - 客体络合，以及我们第一次报告CB [7]对TM与斑马鱼模型引起的全身麻醉的逆转效果。这些发现可能导致一种新的方法，可以让患者恢复早乐的速度比他们从全身麻醉的自然恢复更快，并且还可以用于逆转一些患者遇到的危及危及患者的危及危及患者的毒性毒性，以应对全身麻醉。

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