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首页> 外文期刊>RSC Advances >A continuous method to prepare poorly crystalline silver-doped calcium phosphate ceramics with antibacterial properties
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A continuous method to prepare poorly crystalline silver-doped calcium phosphate ceramics with antibacterial properties

机译：一种连续的方法，制备具有抗菌性能的良好结晶银掺杂磷酸钙陶瓷的方法

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Silver-doped calcium phosphate ceramics were prepared in discontinuous and continuous processes with different amounts of incorporated silver (up to 1.8 wt% silver). In particular, the effects of pH, reaction time and light exposure on the incorporation of silver into the calcium phosphate ceramic were investigated. In the dark, silver can be incorporated as colourless silver ions (Ag ~(+) ) into the apatite lattice, but the integration occurs slowly. Under ambient light, a rapid photoreduction to elemental silver (Ag ~(0) ) occurs which permits a continuous process to prepare silver-doped calcium phosphate ceramics. The silver-doped calcium phosphate ceramics were characterized by scanning electron microscopy, X-ray powder diffraction, infrared spectroscopy, thermogravimetry, and elemental analysis (Ca, Ag, phosphate). The silver release from the silver-doped calcium phosphate ceramics was measured by a combination of dialysis and atomic absorption spectroscopy. The antimicrobial effect was tested on bacteria ( Escherichia coli ), and the cytotoxic effect was tested on HeLa cells (human epithelial cervical cancer cells). For comparison, stoichiometric silver phosphate, Ag _(3) PO _(4) , was prepared. The release of silver from silver phosphate is much faster, leading to pronounced antibacterial but also cytotoxic effects.
机译：用不同量的掺入银（高达1.8wt％银）的不连续和连续的方法制备银掺杂磷酸钙陶瓷。特别地，研究了pH，反应时间和光暴露对银掺入磷酸钙陶瓷中的影响。在黑暗中，银可以作为无色银离子（Ag〜（+））掺入磷灰石晶格中，但积分缓慢发生。在环境光下，发生对元素银（Ag〜（0））的快速光电，这允许连续的方法制备银掺杂磷酸钙陶瓷。通过扫描电子显微镜，X射线粉末衍射，红外光谱，热重率和元素分析（CA，Ag，磷酸盐），表征银掺杂磷酸钙陶瓷。通过透析和原子吸收光谱的组合测量来自掺杂银磷酸钙陶瓷的银释放。在细菌（大肠杆菌）上测试抗微生物效应，并在HeLa细胞（人上皮宫颈癌细胞）上测试细胞毒性效果。为了比较，制备了化学计量银磷酸盐，Ag _（3）PO _（4）。银磷酸盐中银的释放要快得多，导致明显的抗菌性，但也是细胞毒性作用。

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