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Usage of different vessel models in a flow-through cell in vitro study of a novel coated balloon catheter

机译：新型涂层气球导管的流通细胞中不同血管模型的用途

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Drug-coated balloon catheters are a novel clinical treatment alternative for coronary and peripheral artery diseases. Calcium alginate, poly(vinylethylimidazolium bromide) and polyacrylamide hydrogels were used as vessel models in this in vitro study. In comparison to a simple silicone tube their properties can be easily modified simulating different types of tissue. Local drug delivery after balloon dilation in the first crucial minute was determined in a vessel-simulating flow-through cell by a simulated blood stream. Balloon catheters were coated with paclitaxel using the ionic liquid cetylpyridinium salicylate as a novel carrier. Drug transfer from coated balloon catheters to different simulated vessel walls was evaluated and compared to a silicone tube. The highest paclitaxel delivery upon dilation was achieved with calcium alginate as the vessel model (60%) compared to polyacrylamide with 20% drug transfer. The silicone tube showed the least amount of wash-off (<1%) by a simulated blood stream after one minute from the vessel wall. The vessel-simulating flow-through cell was combined with a model coronary artery pathway to estimate drug loss during simulated use in an in vitro model. Calcium alginate and polyacrylamide hydrogels were used as tissue models for the simulated anatomic implantation process. In both cases, similar transfer rates for paclitaxel upon dilation were detected.
机译：药物涂层球囊导管是一种新型临床治疗替代冠状动脉和外周血动脉疾病。在该体外研究中使用藻酸钙，聚（乙烯基乙基咪唑溴铵）和聚丙烯酰胺水凝胶作为血管模型。与简单的硅树脂管相比，它们的性质可以容易地修改模拟不同类型的组织。通过模拟血液流在血管上的流通细胞中测定第一关键微小的局部药物递送。使用水杨酸酯作为新载体的离子液体甲基吡啶鎓涂覆球囊导管。评价从涂覆的球囊导管到不同模拟容器壁的药物转移，并与硅树脂进行比较。与聚丙烯酰胺具有20％药物转移的聚丙烯酰胺相比，通过作为血管模型（60％）实现的最高紫杉醇递送。在从容器壁上一分钟后，硅氧烷管通过模拟血流显示了最少的洗涤液（<1％）。血管模拟流通电池与模型冠状动脉途径组合，以在体外模型中模拟使用期间估计药物损失。使用藻酸钙和聚丙烯酰胺水凝胶作为模拟解剖植入过程的组织模型。在这两种情况下，检测到紫杉醇在扩张时的类似转移率。

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