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首页> 外文期刊>RSC Advances >Reversible response of poly(aspartic acid) hydrogels to external redox and pH stimuli
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Reversible response of poly(aspartic acid) hydrogels to external redox and pH stimuli

机译：聚（天冬氨酸）水凝胶对外氧化还原和pH刺激的可逆反应

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摘要

A redox- and pH-responsive poly(aspartic acid) (PASP) hydrogel is synthesised by cross-linking cysteamine modified polysuccinimide (PSI) with non-cleavable cross-linker 1,4-diaminobutane followed by the hydrolysis of the resultant PSI gel to a PASP hydrogel. The hydrogel showed a remarkable change in its degree of swelling as a function of external pH because of the polyelectrolyte character of the network. In addition to pH-dependent swelling, the thiolation of the polymer rendered redox responsive behaviour to poly(aspartic acid). The degree of swelling could be tuned in a reversible manner by immersing the hydrogel in reducing or oxidising media. The elastic modulus of the hydrogel was also strongly affected by the presence of reducing or oxidising agents. Moreover, the gel strength could be improved via oxidation. The reversible response of the degree of swelling and the elastic modulus was induced through the thiol–disulphide transformation inside the hydrogel proven using a new analytical method. Consequently, a dual responsive hydrogel is obtained with redox-tunable cross-link density.
机译：通过用不可切割的交联剂1,4-二氨基丁烷交联半胱胺改性的聚琥珀酰亚胺（PSI），然后通过将所得PSI凝胶的水解进行交联半胱胺改性的聚琥珀酰亚胺（PSI）来合成氧化还原和pH响应性聚（PsaP）水凝胶。皮带水凝胶。由于网络的聚电解质特征，水凝胶显示出其作为外部pH的函数的溶胀程度显着变化。除了pH依赖性溶胀之外，聚合物的硫醇化将氧化还原响应性呈给聚（天冬氨酸）。通过将水凝胶浸入还原或氧化培养基中，可以以可逆的方式调谐溶胀程度。水凝胶的弹性模量也受到还原剂或氧化剂存在的强烈影响。此外，通过氧化可以改善凝胶强度。通过使用新的分析方法通过水凝胶内的硫醇 - 二硫化物转化诱导肿胀程度和弹性模量的可逆响应。因此，用氧化还原可调的交联密度获得双敏化水凝胶。

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