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首页> 外文期刊>Scientific reports. >Analysis of Optic Chiasmal Compression Caused by Brain Tumors Using Optical Coherence Tomography Angiography
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Analysis of Optic Chiasmal Compression Caused by Brain Tumors Using Optical Coherence Tomography Angiography

机译：光学相干断层造影血管造影脑肿瘤引起的视神经压缩压缩分析

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We have quantitatively evaluated the macular and peripapillary microvascular changes in eyes with chiasmal compression caused by brain tumors compared with healthy control eyes using optical coherence tomography angiography (OCT-A) and correlated them with other ocular parameters. This cross-sectional study involved the analysis of 36 eyes of 36 patients with chiasmal compression and age and refractive error-matched 35 healthy control eyes. OCT-A was used to generate microvascular images of the superficial and deep retinal capillary plexus (SRCP, DRCP) and the radial peripapillary capillary (RPC) segment in the macula and peripapillary areas. Automated segmentation and vessel density measurements facilitated the analysis of each layer. Macular OCT-A analysis revealed a significant reduction in vessel density in the SRCP (P?=?0.004) of the nasal quadrant (P??0.001) and in the same quadrant of the DRCP (P?=?0.019) in the eyes with chiasmal compression compared with the control eyes. The RPC segment vessel density has also been significantly reduced in the eyes with chiasmal compression (P??0.001). The RPC segment and the SRCP vessel densities were correlated with the peripapillary retinal nerve fiber layer and the ganglion cell layer complex thicknesses. The RPC segment and the nasal quadrant SRCP and the DRCP vessel densities were correlated with visual field defect. Significant microvascular alterations have been detected in the eyes with chiasmal compression compared with the control eyes. This study confirmed that chiasmal compression caused by brain tumors not only induced a loss of ganglion cells but also resulted in intra-retinal microvascular changes.
机译：通过使用光学相干断层造影血管造影（OCT-A）与健康对照眼相比，我们已经定量评估了眼睛的眼睛和围毛绒微血管变化与脑肿瘤引起的脑肿瘤相比，并将它们与其他眼参数相关联。这种横截面研究涉及36名患者的三次患者36名Chiasmal压缩和年龄和屈光误差匹配的35例健康对照眼。 OCT-A用于产生浅表和深视网膜毛细血管丛（SRCP，DRCP）和径向围毛皮毛细血管（RPC）区段的微血管图像在黄斑和产兆状区域。自动分割和血管密度测量促进了每层的分析。黄斑OCT-A分析显示鼻象限（P？<0.001）的SRCP（P？= 0.004）中的血管密度的显着降低（P？<0.001），在DRCP（P？= 0.019）的相同象限中与Chiasmal压缩的眼睛与控制眼相比。 RPC段血管密度也被Chiasmal压缩的眼睛显着降低了（P？<0.001）。 RPC段和SRCP血管密度与百毛细管视网膜神经纤维层和神经节细胞层复合物厚度相关。 RPC段和鼻象限SRCP和DRCP血管密度与视野缺陷相关。与对照眼相比，在Chiasmal压缩中检测到显着的微血管改变。本研究证实，脑肿瘤引起的Chiasmal压缩不仅诱导了神经节细胞的丧失，而且导致视网膜内微血管变化。

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