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首页> 外文期刊>Scientific reports. >In vivo imaging of the hyaloid vascular regression and retinal and choroidal vascular development in rat eyes using optical coherence tomography angiography
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In vivo imaging of the hyaloid vascular regression and retinal and choroidal vascular development in rat eyes using optical coherence tomography angiography

机译：使用光学相干断层造影血管造影的封锁血管回归和视网膜血管回归和视网膜和脉络膜血管发育的体内成像

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This study investigates the hyaloid vascular regression and its relationship to the retinal and choroidal vascular developments using optical coherence tomography angiography (OCTA). Normal and oxygen-induced retinopathy (OIR) rat eyes at postnatal day 15, 18, 21, and 24 were longitudinally imaged using OCTA. At each day, two consecutive imaging for visualizing the hyaloid vasculature and the retinal and choroidal vasculatures were conducted. The hyaloid vessel volume and the retinal and choroidal vessel densities were measured. The hyaloid vessel volumes gradually decreased during the regression, although the OIR eyes exhibited large vessel volumes at all time points. A spatial relationship between persistent hyaloid vasculature and retardation of underlying retinal vascular development was observed in the OIR eyes. Furthermore, anti-vascular endothelial growth factor (VEGF) was administered intravitreally to additional OIR eyes to observe its effect on the vascular regression and development. The VEGF injection to OIR eyes showed reduced persistent hyaloid vessels in the injected eyes as well as in the non-injected fellow eyes. This study presents longitudinal imaging of intraocular vasculatures in the developing eye and shows the utility of OCTA that can be widely used in studies of vascular development and regression and preclinical evaluation of new anti-angiogenic drugs.
机译：本研究通过光学相干断层造影血管造影（OctA）研究了透明质血管回归及其与视网膜和脉络膜血管发育的关系。在后期15,18,21和24日在后期和氧气诱导的视网膜病（oIr）大鼠眼睛使用Octa纵向成像。在每一天，进行两个连续成像，用于可视化透明质脉管系统和视网膜和脉络膜脉灰。测量透明质血管体积和视网膜和脉络膜血管密度。在回归期间，透耳管体积逐渐降低，尽管在所有时间点都表现出大容器体积。在oir眼睛中观察到持续透明质脉管系统与潜在视网膜血管发育的延迟之间的空间关系。此外，抗血管内皮生长因子（VEGF）被静脉内施用，以额外的oir眼，以观察其对血管回归和发育的影响。对OIR眼的VEGF注射在注射眼中显示出持续的透明血管以及未注射的同伴眼睛。本研究介绍了显影眼中眼内血管的纵向成像，并显示了Octa的效用，可广泛用于血管开发和回归和新的抗血管生成药物的回归和临床前评价。

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