...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Magnetic Resonance Imaging Evaluation ofCerebral Microbleeds A Comparative Analysisof Susceptibility Weighted Imaging and T2*Gradient Recalled Echo Sequences
【24h】

Magnetic Resonance Imaging Evaluation ofCerebral Microbleeds A Comparative Analysisof Susceptibility Weighted Imaging and T2*Gradient Recalled Echo Sequences

机译：脑脊液磁共振成像评价易感性加权成像的比较分析及T2 *梯度召回回忆序列

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cerebral Microbleeds (CMBs) are increasingly recognised as an important predictor of small vessel disease and cannot be detected on routine Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) sequences.Aim: This study was aimed at evaluating CMBs on MRI and to compare the sensitivity of SWI and T2* GRE sequences in detection of these microbleeds. In addition, we also sought to evaluate association between topography (size, number and location) of CMBs and various risk factors.Materials and Methods: This Prospective observational analytical study comprised of 67 patients with CMBs who were evaluated with Siemens 1.5 Tesla MRI machine. T2*-weighted gradient recalled echo sequence and Susceptibility-Weighted Imaging (SWI) were taken in all the patients in addition to routine MRI sequences. Two observers blinded to clinical information, independently interpreted the T2*GRE and SWI sequences. Both observers recorded the topographical details of CMBs which included presence, number, size and location and their association with various risk factors (hypertension, diabetes, smoking and hyperlipidemia). Inter-rater agreement for the number of CMBs on SWI and on T2*GRE was calculated using Cohen’s Kappa (?) as measure of agreement. Intra-Class Correlation Coefficient (ICC) for reliability index in test-retest, intra-rater and interrater reliability was also analysed. The intra-rater reliabilities of each rater were compared. The Correlations between CMBs and risk factors was performed with Pearson’s correlation Coefficient (r). The p-value <0.05 was considered statistically significant.Results: The SWI with its Reverse Phase (RP) detected more number of CMBs as compared to T2*GRE. Majority of the subjects (71.6%) had more than 5 CMBs. CMBs ≥5 mm had a strong correlation with both hypertension and diabetes as compared to CMBs <5 mm. There was a higher frequency of patients with lobar CMBs (89.6%) followed by the deep location (70.1%). An almost perfect agreement was found between both observers for number of CMBs on RP SWI with ‘κ’ value of 0.97a (0.96-0.98) in contrast to a weak agreement on RP T2*GRE with κ=0.52a (0.40-0.64). For SWI, an almost perfect reliability was found (ICC=0.998) as compared to a moderate reliability on T2*GRE (ICC=0.6826). An excellent reliability was seen for size of CMBs <5 mm on RP SWI (ICC 0.998).Conclusion: SWI offered greater reliability and sensitivity for CMB detection as compared to the T2*GRE sequence and is presently the gold standard sequence of MRI for quantifying CMBs. The burden of CMBs may further indicate inappropriately treated hypertension and diabetes.
机译：脑微出血（CMBs的）正日益被视为小血管疾病的重要预测因子，并且不能在常规的计算机断层摄影（CT）或磁共振成像（MRI）序列检测的目的：该研究的目的是在MRI评估CMBs的和SWI和T2 * GRE序列的灵敏度比较检测这些微出血的。此外，我们还试图评估CMBs的各种风险因素的地形（大小，数量和位置）之间的关联材料和方法：由67例CMBs的前瞻性观察分析研究谁是与西门子1.5特斯拉评价MRI机。 T2 *加权梯度回波回波序列和磁化率加权成像（SWI）被采取在所有的患者除了常规MRI序列。失明的临床信息两个观察者独立地解释T2 * GRE和SWI序列。记录两个观察者CMBs的，其中包括存在，数量，大小和位置以及它们与各种风险因素（高血压，糖尿病，吸烟和高脂血症）关联的地形信息。对SWI和T2 * GRE使用科恩的卡帕（？）作为协议的度量计算CMBs的数量跨评价者协议。帧内级相关系数（ICC），用于重测可靠性指标内，评估者和间信还分析。各评价者的帧内评估者的可靠性进行了比较。 CMBs的危险因素的调查与分析与Pearson相关系数（R）进行。 p值<0.05被认为是统计学显著的结果：SWI其反相（RP）检测到的更多的CMBs的数目相比，T2 * GRE。本科目（71.6％）的多数已超过5个CMBs的。相比于CMBs的<5毫米CMBs的≥5毫米有与两个高血压和糖尿病的强相关性。有患者的随后的位置深（70.1％）叶CMBs的（89.6％）更高的频率。一个近乎完美的协议是两个观察者对RP SWI CMBs的与此相反对RP T2 * GRE弱协议0.97a（0.96-0.98）的“κ”值的数量之间发现κ= 0.52a（0.40-0.64） 。对于SWI，几乎完美的可靠性被发现相比于在T2 * GRE（ICC = 0.6826）中等可靠性（ICC = 0.998）。优异的可靠性被认为对于CMBs的<5毫米RP SWI（ICC 0.998）的大小的结论：SWI提供更高的可靠性和灵敏度对CMB检测相比，T2 * GRE序列并且目前的金标准序列MRI量化CMBs的。 CMBs的负担可以进一步指示处理不当高血压和糖尿病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号