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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Application of Haematological Indices in the Diagnosis of Swine Influenza Infection in Adults
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Application of Haematological Indices in the Diagnosis of Swine Influenza Infection in Adults

机译：血液学指数在成人猪流感感染诊断中的应用

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Introduction: The differential diagnoses of patients hospitalisedfor Influenza-Like Illness (ILI) due to swine influenza virus vsother pathogens are challenging.Aim: To evaluate haematological indices such as lymphocyte(LYM), platelet (PLT), Neutrophil-to-Lymphocyte Ratio (NLR),Platelet-to-Lymphocyte Ratio (PLR), and Lymphocyte multipliedby Platelet Count (LYM×PLT) as potential indicators to discriminateswine influenza virus infection from another ILI in Adults.Materials and Methods: This study was conducted among332 patients, admitted with ILI from January 2019 toDecember 2019. Complete Blood Count (CBC) and ReverseTranscriptase-Polymerase Chain Reaction (RT-PCR) to detectswine influenza virus from throat/nasal swab were performedin each patient. Based on results, patients were dividedinto swine influenza-positive and swine influenza-negativegroups. ANOVA test was used to compare different groups.The diagnostic values of the haematological indices in swineinfluenza infection were evaluated, using the ROC curve.p-value <0.05 was considered statistically significant.Results: The haematological indices in patients with swineinfluenza-positive were significantly different as compared toswine influenza-negative and healthy control groups. Additionally,among all the haematological indices, NLR showed the highestdiagnostic value with the Area Under the Curve (AUC) of 0.511with the best sensitivity and specificity of 55.1% and 48.1%,respectively, if the swine influenza-negative group was used asa reference. Whereas, using controls as a reference, the AUC ofNLR was 1.0 with the best sensitivity and specificity of 100% each.The best sensitivity and specificity of PLR was 46.1% and 46.9%,if the swine influenza-negative group was used as a reference.Conclusion: Combination of the NLR values more than 3.09and the PLR values more than 130.53 may indicate swineinfluenza infection in adults. NLR and PLR value can be used toascertain, whether the patient who presented as ILI, is infectedwith Swine Influenza.
机译：介绍：由于猪流感病毒的患者病患者患者的差异诊断vsother病原体是挑战.aum：以评估淋巴细胞（Lym），血小板（PLT），中性粒细胞对淋巴细胞比例等血液学指数（ NLR），血小板到淋巴细胞比（PLR）和淋巴细胞增加的血小板计数（LYM×PLT）作为潜在指标，以鉴别成人中另一种ILI的潜在ILI的潜在指标。材料和方法：本研究在332名患者中进行，承认Ili从2019年1月到2019年1月。从喉/鼻拭子中，完成血统计数（CBC）和REVERSERCRAPSICHA酶 - 聚合酶链式反应（RT-PCR）从喉/鼻拭子中检测血液流感病毒。基于结果，患者分开猪流感阳性和猪流感 - 负群。 ANOVA测试用于比较不同的群体。评估SKOC曲线感染中血液学指数的诊断价值，使用ROC CURVE.p-VALUE <0.05被认为是统计学意义。结果：SKUAZFLUZA-阳性患者的血液学指数显着显着与培胺流感阴性和健康对照组相比不同。此外，在所有血液学指数中，NLR分别显示出曲线（AUC）下的区域的最高诊断值，其中0.511，如果猪流感阴性组分别用于参考，则分别为55.1％和48.1％的最佳敏感性和特异性。 。尽管使用对照作为参考，但AUCNLR为1.0，最佳敏感性和1％的特异性。如果猪流感阴性组用作参考，则PLR的最佳敏感性和特异性为46.1％和46.9％ .Conclusion：NLR值的组合大于3.09和PLR值超过130.53，可以表明成人中的Skyinfluenza感染。可以使用NLR和PLR值对，是否呈现为伊利的患者，感染了猪流感。

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