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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Role of Pleural Fluid C-Reactive Protein in the Aetiological Diagnosis of Exudative Pleural Effusion
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Role of Pleural Fluid C-Reactive Protein in the Aetiological Diagnosis of Exudative Pleural Effusion

机译：胸膜液C反应蛋白在渗透胸腔积液的诊断中的作用

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Pleural effusions, the result of the accumulation of fluid in the pleural space, are a major diagnostic problem due to its anatomical nature with no direct access. There is variation in management, depending on the pleural disease. The pleural effusion can either exhibit specific or nonspecific characteristics.Aim: To determine the clinical significance and diagnostic role of pleural fluid C-Reactive Protein (CRP) level in the aetiological diagnosis of exudative pleural effusion.Materials and Methods: This was a cross-sectional study performed during the study period of September 2013 to December 2014. A total of 53 Patients identified with pleural effusion were recruited in the study and pleural fluid was subjected for the measurement of CRP level. Pleural fluid CRP was assessed with CRP-Turbilatex-Quantitative turbidimetric immunoassay method which is based on the principle agglutination reaction. The data was subjected to statistical analysis using Epi info software version 3.4.3. The ROC curve was plotted to illustrate the diagnostic ability. The smallest cut-off value was the minimum observed test value minus 1, and the largest cut-off value was the maximum observed test value plus 1. All the other cut-off values were the averages of two consecutive ordered observed test values.Results: Among the 53 patients in the study, 42 had exudative effusions (79.20%) and 11 had transudative effusions (20.80%). The common cause of exudative effusion was tuberculosis 26 (61.90%), followed by 9 malignancy (21.40%) and 7 parapneumonic effusion (16.70%). In our study, the pleural fluid CRP was statistically significant (p<0.001) marker to differentiate exudative effusions with CRP-value 70 mg/L suggestive of parapneumonic effusions.Conclusion: Determination of pleural fluid CRP is a useful diagnostic marker for differentiating exudative and transudative effusions. Also, Pleural fluid CRP is a statistically significant marker in differentiating tubercular effusions from nontubercular exudative effusions.
机译：胸腔有效，胸腔空间中流体积累的结果，是由于其解剖性，没有直接访问的主要诊断问题。管理层有变异，取决于胸膜疾病。胸腔积液可以表现出特异性或非特异性特征。目的：确定胸腔流体C反应蛋白（CRP）水平在渗透性胸腔积液的安全性诊断中的临床意义和诊断作用。材料和方法：这是2013年9月至2014年12月期间进行的横断面研究。在研究中招募了患有胸腔积液的53名患者，并且对CRP水平进行胸腔液进行胸腔。用CRP - 浊X定量浊度免疫测定法评估胸膜液CRP，其基于原理凝集反应。使用EPI INFO软件3.4.3版进行数据进行统计分析。 ROC曲线被绘制以说明诊断能力。最小的截止值是最小观察到的测试值减去1，最大的截止值是最大观察到的测试值加1.所有其他截止值是两个连续有序观察到的测试值的平均值。< B>结果：在研究中的53名患者中，42例具有渗出性积液（79.20％），11例具有转潜力的积液（20.80％）。渗出性积液的常见原因是结核病26（61.90％），其次是9个恶性肿瘤（21.40％）和7例横向的积液（16.70％）。在我们的研究中，胸腔流体CRP具有统计学意义（p <0.001）标记，以区分渗出性含量的渗出术的渗透性湿度的含量。结论：胸腔流体CRP的测定是一种有用的诊断标志物消除渗出性和经过塑化的潮流。此外，胸腔流体CRP是一种统计学上显着的标记，用于区分来自非乌伯氏渗透性的渗透性的微分效果。

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