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Neuroleptic Malignant Syndrome Presenting with Self Injurious Behaviour

机译:具有自我伤害行为的神经抑制性恶性综合征

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Neuroleptic Malignant Syndrome (NMS) is an emergency condition produced as an ill effect of certain drugs. Tetrad of symptomsincludes fever, muscle rigidity, autonomic features and altered mental status. Pathophysiology underlying this condition isdopamine receptor blockade or depletion of dopamine. Author presented a case of 45-year-old female, alcoholic with symptomsof self-mutilating behaviour such as fnger biting and tongue bites, elevated Creatine Phosphokinase (CPK) levels and no signs ofautonomic dysfunction. Differential diagnosis included was malignant hyperthermia, neuroleptic malignant syndrome, serotoninsyndrome, lethal catatonia, meningitis/encephalitis, heat stroke and anticholinergic toxicity. Final diagnosis of neuroleptic malignantsyndrome was made according to Caroff SN and Mann SC criteria. She was treated with bromocriptine with an improvement in hercondition. Clear workup including identifcation of other systemic and neuropsychiatric conditions with overlapping symptoms isimportant for accurate diagnosis of this condition.
机译:神经抑制性恶性综合征(NMS)是一种作为某些药物效果产生的应急状况。征收症状的四肢症状,肌肉刚性,自主特征和精神状态改变。这种条件下面的病理生理学是多巴胺受体阻断或耗尽多巴胺。作者提出了一个45岁的女性,含有自残行为的症状,如FGER咬和舌叮咬,肌肉磷酸胨(CPK)水平升高,无象征功能障碍的迹象。差异诊断包括恶性热疗,神经抑制性恶性综合征,血清肾上腺素,致死的肾上腺炎,脑膜炎/脑炎,中暑和抗胆碱能毒性。根据Caroff Sn和Mann SC标准制作了神经抑制的Malignantsyndrome的最终诊断。她用溴杉木对待,改善了Hercondition。清除后化,包括识别其他全身和神经精神病症,其具有重叠症状,以便准确诊断这种情况。

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