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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Histopathological Types of Benign Proliferative Lesions in Peritumoural Vicinity of Carcinoma Breast
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Histopathological Types of Benign Proliferative Lesions in Peritumoural Vicinity of Carcinoma Breast

机译：脑乳腺癌腹膜附近的良性增殖病变组织病理学类型

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The majority (90%) of lesions that occur in the breast are benign. In India, although benign breast diseases had a high incidence they have always been overshadowed clinically by breast cancer. Retrospective and prospective studies have shown relative risk of breast cancer of 1.5 to 1.6 for women with benign breast disease as compared with women in the general population. The presence of different lesions within the same breast adjacent to malignancy is also a phenomenon that can prove the multistep progression to malignancy.Aim: To determine the presence of any change in peritumoural area of carcinoma breast and to compare the pathological findings of tumour and adjacent area for co-existing benign proliferative lesions.Materials and Methods: The prospective, cross-sectional and observational study included 75 cases of mastectomy specimens of carcinoma breast conducted in the histopathology section of Department of Pathology, Jawaharlal Nehru Medical College (JNMC) in Sawangi (M) Wardha, from 1~(st) August 2017 to 31~(st) July 2019. The cases in which the histopathological diagnosis of infiltrating ductal carcinoma-not otherwise specified were made on Haematoxylin and Eosin (HandE) staining. Sections of the tumour and peritumoural area were studied in detail for co-existing lesions. Based on the predominant epithelial benign lesion present in peritumoural area, the lesions were classified morphologically as: Non-proliferative, Proliferative disease without atypia and Proliferative disease with atypia. Statistical analysis was done using descriptive and inferential statistics with the chi-square test and software used in the analysis were SPSS 24.0 version and GraphPad Prism 7.0 version.Results: Out of 75 cases diagnosed as carcinoma breast on HandEfurther peritumoural area was subcategorised as 29 cases of fibrocystic changes (38.67%), 8 cases of proliferative disease without atypia (10.66%) and 33 cases of proliferative disease with atypia (44%) associated with tumour.Conclusion: The study concludes that the most predominant histological lesions in peritumoural area of carcinoma breast are proliferative changes with atypia followed by fibrocystic changes which has an absolute lifetime risk of 13-17% transforming into carcinoma breast making these patients mandatory for follow-up and further management.
机译：乳房发生的大多数（90％）的病变是良性的。在印度，虽然良性乳腺疾病的发病率很高，但它们一直被乳腺癌临床透明地在临床上黯然失色。与一般人群中的女性相比，回顾性和前瞻性研究表明患有良性乳腺疾病的患者的乳腺癌的相对风险为1.5至1.6。与恶性肿瘤相邻的同一乳房内不同病变的存在也是一种现象，可以证明对恶性肿瘤的多步进程。目的：确定癌乳腺癌患者面积发生任何变化的存在，并比较病理结果肿瘤和邻近地区用于共同存在的良性增殖性病变。材料和方法：前瞻性，横截面和观察研究包括75例癌症病理学组织病理学部门进行的癌乳腺乳房切除术标本，Jawaharal Nehru Medical大学（JNMC）在Sawangi（M）Wardha，2017年8月1日〜（ST）至2019年7月31〜（ST）。在血液毒素和曙红中未另行指定的浸润导管癌的组织病理学诊断的病例（手工染色。对共存病变进行了详细研究了肿瘤和腹部肿瘤区域的部分。基于腹膜面积的主要上皮良性病变，病变在形态学上被分类为：未增殖的，增殖性疾病，无缺点和具有缺点的增殖疾病。使用描述性和推理统计数据进行统计分析，分析中使用的Chi-Square测试和软件是SPSS 24.0版本和GraphPad Prism 7.0版本。结果：超过75例诊断为CarcoTher Pertuber患者的癌乳房区域分类作为29例纤维囊性变化（38.67％），8例增殖性疾病，无阿薄膜（10.66％）和33例与肿瘤有关的非典型增殖性疾病（44％）。结论：该研究得出结论，最主要的癌乳腺癌患者的组织学病变是Atypia的增殖性变化，然后具有纤维囊性变化，其具有13-17％转化为癌母乳的绝对寿命风险，使这些患者用于跟进和进一步管理。

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