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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of Brain Tumours using Magnetic Resonance Perfusion Imaging: A Prospective Study
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Evaluation of Brain Tumours using Magnetic Resonance Perfusion Imaging: A Prospective Study

机译：使用磁共振灌注成像评估脑肿瘤：一项前瞻性研究

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Brain tumours are an important cause of neurological problems. Grade of these tumours is one of the parameters which decide the treatment offered to patients. Magnetic Resonance Imaging (MRI) though superior to other conventional modalities still has few limitations in assessing grade of tumours. Perfusion MRI by virtue of its ability to measure haemodynamic parameters can be used to access grade of tumour.Aim: To evaluate the role of perfusion MRI in evaluation of brain tumours by using relative Cerebral Blood Volume (rCBV).Materials and Methods: A prospective study was carried out in a tertiary care hospital from July 2015 to June 2018. MRI was performed on 23 patients using conventional imaging, perfusion imaging with T2*-weighted Echo-Planar sequence after administration of Gadopentetate dimeglumine. Perfusion data was processed to obtain colour maps and rCBV value was generated. rCBV values were correlated with histopathological grade of tumours. Statistical analysis was done by using SPSS (Statistical Package for Social Sciences) Version 20.0. Tukeya??s test was used to compare the mean rCBV value for pairwise comparison of grades of tumour and unpaired t-test was used to compare the mean rCBV between high grade and low grade astrocytomas. Receivera??s Operating Characteristics (ROC) curve was used to find the sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) and cut-off value of rCBV for detection of high grade tumour.Results: Grade I astrocytoma and Grade II astrocytoma had mean rCBV of 1.435±1.063 and 2.046±1.282, respectively. Grade III astrocytoma and Grade IV astrocytoma had mean rCBV of 7.620±3.463 and 12.455±0.361 respectively. Mean rCBV of medulloblastoma was 4.185±2.482. Low grade astrocytoma (grade I and grade II) had mean rCBV of 1.817±1.207 and high grade astrocytoma (grade III and grade IV) had mean rCBV of 9.554±3.611. There was significant difference between mean rCBV in Grade I/II vs III/IV (p<0.001), there was no significant difference between mean rCBV in Grade I and Grade II.Conclusion: Perfusion MRI is useful in differentiating low grade (grade I and II) astrocytoma from high grade (grade III and IV) astrocytoma.
机译：脑肿瘤是神经问题的重要原因。这些肿瘤的等级是决定患者提供的治疗的参数之一。磁共振成像（MRI）虽然优于其他常规方式仍然在评估肿瘤等级时仍有很少的限制。灌注MRI通过测量血液动力学参数的能力可用于访问肿瘤等级。目的：评估灌注MRI的作用通过使用相对脑血量（RCBV）评估脑肿瘤的评估。材料和方法：2015年7月至2018年6月，在第三次护理医院进行了预期研究。MRI由23名使用常规成像，灌注成像与T2 * - 重量的回声平面序列在施用钆甲酸酯二聚体后进行MRI。处理灌注数据以获得颜色图，并产生RCBV值。 RCBV值与肿瘤的组织病理学等级相关。通过使用SPSS（社会科学统计包）20.0版完成统计分析。 Tukeya？S试验用于比较肿瘤等级的成对比较的平均RCBV值，并且使用未配对的T检验来比较高级和低级星形细胞瘤之间的平均RCBV。 Receivera的操作特性（ROC）曲线用于找到敏感性，特异性，阳性预测值（PPV）和负预测值（NPV）和RCBV的截止值，用于检测高级肿瘤。结果：I级星形细胞瘤和II级星形细胞瘤的平均RCBV分别为1.435±1.063和2.046±1.282。 III级星形细胞瘤和IV级星形细胞瘤的平均rcbv分别为7.620±3.463和12.455±0.361。 Medulloblastoma的平均RCBV为4.185±2.482。低级星形细胞瘤（I级和II级）的平均RCBV为1.817±1.207，高级星形细胞瘤（III级和IV级）的平均RCBV为9.554±3.611。平均RCBV在等级I / III / IV中存在显着差异（P <0.001），平均I和II级的平均RCBV之间没有显着差异。结论：灌注MRI可用于区分低等级（I和II级）高级（III级和IV等级）星形细胞瘤的星形细胞瘤。

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