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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Lipid Profile and C-Reactive Protein Levels in Healthy, Overweight and Obese Adults: A Hospital-based Observational Study
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Lipid Profile and C-Reactive Protein Levels in Healthy, Overweight and Obese Adults: A Hospital-based Observational Study

机译：健康，超重和肥胖成年人的脂质型材和C反应蛋白水平：一项基于医院的观察研究

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Numerous biomarkers involved in inflammation have been associated with cardiovascular events, out of which high sensitivity-C-Reactive Protein (hs-CRP), an acute-phase protein, appears to be the most promising. The association between dyslipidaemia and obesity is well established in literature and has been found to be risk factor for Cardiovascular Disease (CVD).Aim: To study the levels of lipid profile and hs-CRP and also find out the relationship between hs-CRP and Body Mass Index (BMI) in obesity.Materials and Methods: The present observational study was carried out from June 2018 to August 2018 in Kalpana Chawla Government Medical College, Haryana, India. A total of 100 apparently healthy volunteers, aged 21-60 years were enrolled for this study. The participants were divided on the basis of BMI into three groups; Healthy (normal): 18.5-22.9 kg/m~(2), overweight: 23-24.9 kg/m~(2), and obese ≥25 kg/m~(2). Anthropometric measurements and biochemical investigations were conceded in all the study participants. Lipid profile and hs-CRP levels were estimated on fully automated clinical chemistry analyser. Statistical analysis was conducted using IBM SPSS statistics (version 22.0). A p<0.05 was considered as significant level.Results: The median levels of HDL were the lowest in the obese group and a statistically significant difference was observed in HDL levels between healthy and obese group (z=3.190, p=0.001) and between overweight and obese group (z=2.760, p=0.006). The median hs-CRP levels were highest in the obese group and statistically significant difference was observed between healthy and overweight group (z=2.009, p=0.044) and between healthy and obese group (z=2.849, p=0.004). A significant positive correlation was observed between BMI and hs-CRP levels (r=0.302, p<0.002). It was further observed that 17 subjects of obese group had hs-CRP levels greater than 3 mg/L as compared to eight of healthy group and nine of overweight group.Conclusion: The subjects of the obese group are at the highest risk of CVD. Hence, they need to be considered for future development. However, abnormalities of lipid metabolism were not observed in the obese study subjects.
机译：涉及炎症的许多生物标志物已经与心血管事件有关，其中高灵敏度-C反应性蛋白（HS-CRP），急性期蛋白质似乎是最有前途的。腹腔血症和肥胖之间的关联在文学中得到了很好的成熟，已被发现是心血管疾病的危险因素（CVD）。目的：研究脂质曲线和HS-CRP的水平，也找出了HS之间的关系-CRP和体重指数（BMI）在肥胖症中。材料和方法：目前的观察研究于2018年6月至2018年8月在Kalpana Chawla政府医学院，印度哈里亚纳纳。共有100岁的志愿者共有100岁的志愿者入学。参与者将BMI分为三组;健康（正常）：18.5-22.9 kg / m〜（2），超重：23-24.9 kg / m〜（2），肥胖≥25kg/ m〜（2）。所有研究参与者都承认了人类测量的测量和生化研究。在全自动临床化学分析仪上估计了脂质谱和HS-CRP水平。使用IBM SPSS统计（版本22.0）进行统计分析。 P <0.05被认为是显着的水平。结果：HDL的中值水平是肥胖组中最低的，在健康和肥胖基团之间的HDL水平中观察到统计学上显着差异（Z = 3.190，P = 0.001 ）和超重和肥胖组（Z = 2.760，P = 0.006）。在肥胖组中，中位HS-CRP水平最高，在健康和超重组（Z = 2.009，P = 0.044）和健康和肥胖基团之间（Z = 2.849，P = 0.004）之间观察到统计学上显着差异。在BMI和HS-CRP水平之间观察到显着的正相关（R = 0.302，P <0.002）。进一步观察到，与八个健康组和九个超重群相比，17个肥胖基团受试者的HS-CRP水平大于3mg / L. 结论：肥胖基团的主题是最高风险CVD。因此，他们需要考虑未来的发展。然而，在肥胖研究受试者中未观察到脂质代谢异常。

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