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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Expression of Immunohistochemical Markers (CD56 and P63) in Various Non-Neoplastic and Neoplastic Lesions of Thyroid Gland
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Expression of Immunohistochemical Markers (CD56 and P63) in Various Non-Neoplastic and Neoplastic Lesions of Thyroid Gland

机译：免疫组织化学标志物（CD56和P63）在甲状腺各种非肿瘤和肿瘤病变中的表达

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Introduction: Thyroid disorders are very common all over India,more so in Kerala. Although defnite histologic criteria exist fordiagnosing various thyroid lesions, there is an overlap of manynuclear and cytoplasmic features like nuclear atypia, enlargementetc., between both non-neoplastic and neoplastic lesions. Thissometimes leads to a diagnostic dilemma in differentiatingthese lesions. CD56 is expressed by many tissues in the bodyincluding normal thyroid follicular epithelium, this expressivitybeing absent or reduced in Papillary Thyroid Carcinoma (PTC).Normal thyroid follicular cells do not express p63. Aberrantexpression of p63 on thyroid epithelium is thus a marker ofproliferation and tumourigenesis.Aim: To assess the expression of CD56 and p63 in various nonneoplastic and neoplastic thyroid lesions and to calculate thepercentage of positivity and negativity in these lesions.Materials and Methods: This was a prospective study of 100thyroidectomy specimens submitted to the Department ofPathology, Govt. TD Medical College, Alappuzha from January2016 to June 2017. HandEstained sections of these specimenswere studied and Immunohistochemical (IHC) staining withCD56 and p63 markers was performed on all and theirexpressions, positive or negative, were evaluated and expressedas percentage values.Results: Out of 100 thyroidectomy specimens studied, totalnumber of non-neoplastic cases was 58 and neoplastic lesions(benign and malignant) were 42. The most common nonneoplastic lesion was lymphocytic thyroiditis (39/58). Mostcommon malignant thyroid neoplasm was PTC (35/42). CD56showed membranous positivity in 53/58 (91.4%) non-neoplasticlesions and only 4/42 (9.5%) neoplastic lesions. Nuclear positivityfor p63 was seen in only a small proportion (18/100, i.e., 18%)of all lesions.Conclusion: Signifcance of this study lies in the fact that CD56is expressed in most non-neoplastic lesions of thyroid and isfound negative in thyroid malignancies. The p63 even thoughconsidered to be a proliferation marker is negative in most of nonneoplastic as well as neoplastic lesions in the present study.
机译：简介：甲状腺障碍在印度均非常普遍，喀拉拉邦更为普遍。虽然存在缺污组织学标准，但存在各种甲状腺病变，但是核原型核原型和细胞质特征的重叠且核肌瘤，扩大术。，在非肿瘤和肿瘤病变之间。 Thissomsomimes导致诊断困境在不同的病变中。 CD56是由骨髓甲状腺卵泡上皮的许多组织表达，这是乳头状甲状腺癌（PTC）中缺席或降低的表达.Normal甲状腺滤泡细胞不表达P63。甲状腺上皮上P63的畸形是含有硫化和肿瘤的标志物：评估在各种非宝挥和肿瘤甲状腺病变中CD56和P63的表达，并在这些病变中计算阳性和消极性的特征。材料和方法：这是一个加入10年代，加入综述的预期研究。 Alappuzha从2017年1月到2017年6月的TD Medical College.对所有和染色的，染色的这些标本（IHC）染色和免疫组化（IHC）染色，对所有和其表达，阳性或阴性进行了染色，并表达了百分比值。结果：超过100研究了甲状腺切除术标本，非肿瘤案例的全数为58个，肿瘤病变（良性和恶性）为42.最常见的非润肤体病变是淋巴细胞甲状腺炎（39/58）。大多数甲状腺甲状腺肿瘤是PTC（35/42）。 CD56在53/58（91.4％）非肿瘤塑性中的CD56发动机阳性，仅为4/42（9.5％）肿瘤病变。对于所有病变的小比例（18/100，即18％）看到核赋予P63。结论：本研究的意义在于CD56S在甲状腺大多数非肿瘤病变中表达，并且在甲状腺中呈现阴性。恶性肿瘤。 P63即使是在本研究中的大多数非网状塑料和肿瘤病变中的增殖标记也是阴性的。

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