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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Role of Curcumin in Alleviating Symptomatic Oral Lichen Planus: A Systematic Review
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Role of Curcumin in Alleviating Symptomatic Oral Lichen Planus: A Systematic Review

机译：姜黄素在缓解症状口服地衣平面的作用：系统审查

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Oral Lichen Planus (OLP) is a chronic inflammatory, immune mediated disease that affects the oral mucosa and skin. Though conventional therapies have aimed to alleviate the signs and symptoms of OLP, they have side effects. To combat this, trend is towards natural products such as curcumin which has antioxidant, anti-inflammatory and anti-cancer properties.Aim: This systematic review aimed to evaluate the existing literature on the role of curcumin in the alleviation of pain, burning sensation, erythema and ulceration in OLP patients.Materials and Methods: Articles on curcumin in the treatment of oral lichen planus were extensively searched in PubMed, Google scholar, Science direct, Cochrane database using key terms “turmeric extracts”, “curcuma longa”, “curcumin”, “curcuminoids”, “oral lichen planus,” “erosive oral lichen planus” with no year restrictions. Screening was based on title and abstract with preset inclusion and exclusion criteria, and full text articles were procured. Included studies were 7 randomised clinical trial, 2 pilot clinical trial, 3 comparative studies. Primary outcome measure was reduction in pain symptoms and clinical improvement, secondary outcome was to achieve complete healing without recurrence.Results: Publications identified through electronic search revealed 1499 articles, from which twelve studies met inclusion criteria. This systematic review comprised 315 OLP patients, wherein four studies revealed that topical curcumin had no statistically significant difference when compared to corticosteroids in treating pain, burning sensation, erythema and ulceration. In three clinical trials compared with placebo, one study showed statistical significance with increased oral dosage (6000 mg) of curcumin, two were not significant due to its reduced oral dosage (2000 mg). Two studies showed that curcumin was effective with increased concentration. Three studies with no controls were statistically significant in reducing burning sensation and clinical appearance of OLP.Conclusion: Though curcumin exhibited promising effects in alleviating symptomatic OLP, majority of studies were evaluated in very small sample size, hence there is insufficient evidence to draw definitive conclusions. We recommend novel curcumin formulations to increase their bioavailability and to initiate high quality Randomised Controlled Trials (RCT).
机译：口服地衣直升机（OLP）是一种慢性炎症，免疫介导的疾病，影响口腔粘膜和皮肤。虽然常规疗法旨在缓解OLP的迹象和症状，但它们具有副作用。为了打击这一点，趋势是抗氧化纤维，抗炎和抗癌特性的天然产物。目的：这种系统审查旨在评估姜黄素在缓解疼痛中的作用的现有文献， OLP患者中的灼热感，红斑和溃疡。材料和方法：在PubMed，Google Scholar，科学直接，Cochrane数据库中广泛搜查了姜黄素的姜黄素姜黄素，使用关键术语“姜黄提取物”，“ Curcuma longa“，”姜黄素“，”姜黄素“，”口服地衣直升机“，”腐蚀口服地衣直升机“，没有年限限制。筛选基于标题和摘要，预设包含和排除标准，采购了全文文章。包括研究是7次随机临床试验，2试点临床试验，3种比较研究。初级结果措施降低了疼痛症状和临床改善，次要结果是在没有复发的情况下达到完全愈合。结果：通过电子搜索确定的出版物显示1499篇文章，从中达到纳入标准。该系统综述包含315名OLP患者，其中四项研究表明，与治疗疼痛，灼热感，红斑和溃疡的皮质类固醇相比，局部姜黄素没有统计学显着差异。在与安慰剂相比的三次临床试验中，一项研究表明，由于其减少的口服剂量（2000mg），两项研究表现出增加的口服剂量（6000mg）姜黄素（6000mg）。两项研究表明，姜黄素有效浓度增加。在减少OLP的燃烧感觉和临床外观时，没有对照的三项研究在统计学上显着。结论：虽然姜黄素表现出对症状OLP的有希望的效果，但大多数研究在非常小的样本量中评估了证据不足绘制明确的结论。我们推荐新型姜黄素制剂来提高其生物利用度，并开始高质量的随机对照试验（RCT）。

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