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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Serum Lactate Dehydrogenase Levels with Birth Asphyxia in Term Neonates
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Serum Lactate Dehydrogenase Levels with Birth Asphyxia in Term Neonates

机译：血清乳酸脱氢酶水平与出生窒息的术语新生儿

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It is difficult to diagnose birth asphyxia if neonatal records are not available. Serum Lactate Dehydrogenase (LDH) level is an easily accessible tool in most of routine laboratories.Aim: To assess the relation of serum LDH with birth asphyxia in term neonates.Materials and Methods: This was a prospective study, done on 50 asphyxiated newborns (cases) and 50 non asphyxiated term newborns (controls) which were taken from Neonatal Intensive Care Unit (NICU), Department of Paediatrics, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, Haryana, India from November 2017 to September 2019. LDH levels were estimated in 50 non asphyxiated neonates of Cord Blood (CB) at birth and in 50 asphyxiated newborns of CB at birth and at 24 hours of life. Chi-square test, Fischer-exact test and student’s t-test were applied in this study. The Software used to analyse and compute data was SPSS version 20.Results: On comparing the controls and cases, mean LDH of CB was 299.90 U/L vs. 999.04 U/L. Mean LDH level in cases at 24 hours was 1574.72 U/L. LDH (CB) sensitivity was 94% with Confidence Interval (CI) 83.45% to 98.75%, specificity was 90.00% with CI 78.19% to 96.67%. The Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of LDH were estimated as 90.38%, 93.75%, respectively. The LDH (CB) value in mild, moderate and severe asphyxia was 585.33±424.78 U/L, 694.91±444.22 U/L, 1369±672.59 U/L, respectively. The LDH at 24 hours of postnatal life values in mild, moderate, severe asphyxiated newborns were 772.33±108.61 U/L, 1103.69±605.25 U/L, 2457±1019.81 U/L, respectively and it showed a highly significant p-value of <0.001. LDH level at 24 hours had more area under curve so have more diagnostic value than LDH (CB) (0.861 vs 0.725), both timing is good for differentiating asphyxiated and normal neonates.Conclusion: The present study found a good correlation between LDH levels in cases with severity of birth asphyxia. It concluded that LDH at 24 hours is a more accurate time to differentiate newborn with birth asphyxia than without birth asphyxia. The LDH for diagnosis of birth asphyxia can be used in cases without past records or sick newborns which are referred from peripheral hospitals.
机译：如果新生儿记录不可用，难以诊断出窒息。血清乳酸脱氢酶（LDH）水平是大多数常规实验室的易于访问工具。目的：评估血清LDH与术语新生儿患者的关系。材料和方法：这是一项前瞻性研究，在2017年11月，从儿科重症监护室（NICU），从2017年11月，来自新生儿重症监护室（NICU），从2017年11月，来自新生儿重症监护室（NICU）的新生儿重症监护单位（NICU），从2017年11月，从2017年11月开始研究到2019年9月。在出生时，在出生时50个非窒息新生儿（CB）的脐带血（CB）中的LDH水平估计，在出生时和24小时的生命中的窒息新生儿。本研究应用了Chi-Square测试，Fischer-Arctial测试和学生的T检验。用于分析和计算数据的软件是SPSS版本20. 结果：在比较控件和情况时，CB的平均值为299.90 U / L与999.04 U / L.平均LDH水平在24小时的情况下为1574.72 U / L. LDH（CB）敏感性为94％，置信区间（CI）83.45％至98.75％，特异性为90.00％，CI 78.19％至96.67％。 LDH的阳性预测值（PPV）和阴性预测值（NPV）分别估计为90.38％，93.75％。轻度，中度和严重窒息的LDH（CB）值分别为585.33±424.78 U / L，694.91±444.22 U / L，1369±672.59 U / L.在温和，中等，严重窒息的新生儿24小时后24小时的后期寿命值为772.33±108.61 U / L，1103.69±605.25 U / L，2457±1019.81 U / L，它显示出高度显着的p值<0.001。 24小时的LDH水平在曲线下具有更多面积，因此具有比LDH（CB）更高的诊断值（0.861 Vs 0.725），两个时序对于区分窒息和正常的新生儿。结论：本研究发现良好的相关性LDH水平在厌食症严重程度的情况下。它得出结论，在24小时的LDH是一个更准确的时间来区分新生儿与出生窒息而不是出生窒息。用于诊断出生窒息的LDH可以在没有从外围医院提到的记录或生病的新生儿的情况下使用。

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