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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Metabolic Syndrome and its Components in Patients with Rheumatoid Arthritis, and their Association with Disease Activity and Duration
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Metabolic Syndrome and its Components in Patients with Rheumatoid Arthritis, and their Association with Disease Activity and Duration

机译：类风湿性关节炎患者的代谢综合征及其组分及其与疾病活动和持续时间的关联

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Rheumatoid Arthritis (RA) is the most common inflammatory rheumatic disease and there are some concerns about the association of Metabolic Syndrome (MetS) with this disorder. Aim: To evaluate the association between MetS and its components with RA disease activity and chronicity. Materials and Methods: The present investigation was a cross-sectional study on 200 consecutive RA patients (30-60-year-old, all of them female) according to the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) 2010. MetS was diagnosed according to the definition of 2005 National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP) III and International Diabetes Federation (IDF). Disease activity was measured by the 28 joint count of Disease Activity Score (DAS 28), and functional status was evaluated by Health Assessment Questionnaire (HAQ). Disease chronicity was defined as early or established RA, based on disease duration of less or more than six months. Statistical analysis was performed in SPSS version 19 by Student's t-test and chi-square test and ANOVA tests and results were considered significant at p<0.05. Results: The mean age of RA patients was 50.29±6.2 years, and all were female. MetS according to NCEP/ATP III and IDF criteria was present in 109 (54.5%) and 112 (56%) patients. Hyperglycaemia was significantly higher in patients with established active RA (p=0.003), but other MetS components were not different between groups. MetS had more related active disease as assessed by DAS28 and greater disability as assessed by the HAQ (p<0.001). Conclusion: The frequency of MetS was not significantly different in subgroups of RA according to disease activity or duration, but it was found in more than half of RA patients. Comparison of MetS components showed more frequency of hyperglycaemia in patients with active disease.
机译：类风湿性关节炎（RA）是最常见的炎症性风湿性疾病，对这种疾病的代谢综合征（Mets）的关联有一些担忧。 目的：评估Mets及其组分与Ra病活动和慢性的关联。 材料和方法：本研究是根据美国风湿病学院/欧洲联盟对风湿病的200个连续RA患者（30-60岁，所有女性）的横截面研究（ACR / 2010年）2010年。根据2005年国家胆固醇教育计划成人处理小组III（NCEP / ATP）III和国际糖尿病联合会（IDF）的定义，诊断出METS。通过28例疾病活动评分（DAS 28）的关节计数来测量疾病活性，通过健康评估问卷（HAQ）评估功能状况。疾病慢性定义为早期或成立的RA，基于疾病持续时间较少或超过六个月。通过学生的T-Test和Chi-Square测试和Chi-Square测试和Chi-Square测试和结果在P <0.05中被认为是显着的统计学分析。 结果：RA患者的平均年龄为50.29±6.2岁，所有是女性。根据NCEP / ATP III和IDF标准的MET出现在109（54.5％）和112名（56％）患者中存在。患者患者的高血糖显着高（P = 0.003），但在组之间的其他METS组分没有差异。 Mets通过DAS28评估和通过HAQ评估的DAS28评估具有更多相关的活性疾病（P <0.001）。 结论：根据疾病活动或持续时间，Mets的频率在RA的亚组中没有显着差异，但在超过一半的RA患者中发现。 Mets组分的比较显示出患有活性疾病患者的高血糖血症频率。

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