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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Second New Primary PNET of Kidney in a Treated Case of Carcinoma Breast: A Case Report
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Second New Primary PNET of Kidney in a Treated Case of Carcinoma Breast: A Case Report

机译：肾脏的第二个新初级PNET在癌乳腺癌的病例中：案例报告

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Primitive Neuroectodermal Tumour (PNET) is a member of small round cell “Blue tumour” family. The overall incidence of PNET is <1%. PNET of kidney is uncommon and was first reported in 1975. Since the first report around 150 cases have been published in medical literature. It exhibits highly aggressive behaviour. It usually affects young adults and has a male predominance of 3:1. Only six cases of PNET of kidney have been reported in older patients and PNET of kidney as a second new primary has rarely been reported, only three cases of renal PNET with history of an earlier or synchronous primary cancer were reported in literature from the USA, Germany and China. Here, the author reported a case of renal PNET in a 48-year-old female who has been treated for right breast cancer by surgery, adjuvant chemotherapy and radiotherapy three years (July 2015) prior to diagnosis of PNET of left kidney. Upon diagnosis, patient underwent left nephrectomy. Postoperatively, patient was started on Ewing’s Family of Tumours (EFT) 2001 protocol. Patient completed induction therapy followed by radiation to tumour bed with concurrent weekly single agent vincristine and was planned for maintenance chemotherapy. After one cycle of maintenance chemotherapy, patient developed severe febrile pancytopenia and was admitted in the ICU, even after aggressive medical line of management, patient could not be revived. Although, the patient tolerated the treatment protocol for breast malignancy well and the primary was under control but after three years, with the diagnosis of a very rare second new primary PNET of left kidney which has a very aggressive nature and poor prognosis, the patient could not tolerate the multimodality treatment which was required.
机译：原始神经分区瘤（PNET）是小圆形细胞“蓝肿瘤”家族的成员。 PNET的总发病率<1％。 PENT肾脏不常见，并于1975年首次报道。由于第一次报告大约150例案件发表于医学文献。它表现出高度侵略性的行为。它通常会影响年轻的成年人，并具有3：1的男性优势。在肾脏的老年患者中仅报告了肾脏的6例，作为第二次新的肾脏，很少报道，只有三种肾PNET患有早期或同步原发癌的历史，来自美国的文献中，德国和中国。在这里，提交人报告了一个48岁女性的肾PNet案例，在左肾PNET之前（2015年7月）在诊断前（2015年7月）进行右乳腺癌治疗右乳腺癌。在诊断后，患者接受左肾切除术。术后，患者始于Ewing的肿瘤系列（EFT）2001议定书。患者完成的感应疗法随后用同时每周单剂量致毒剂辐射辐射，并计划进行维持化疗。经过一个循环维持化疗，患者发育严重的巨乳特迟，并且在ICU中被录取，即使经过积极的医疗管理，患者无法复苏。虽然患者耐受乳腺恶性肿瘤的治疗方案，但主要是对照但三年后，诊断为左肾的一个非常罕见的第二初级PNET，具有非常侵略性的性质和预后差，患者可以不容忍所需的多模态处理。

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