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首页> 外文期刊>Journal of the National Medical Association >Hospital Admissions, Mortality and Comorbidities Among New York State Sickle Cell Patients, 2005-2013
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Hospital Admissions, Mortality and Comorbidities Among New York State Sickle Cell Patients, 2005-2013

机译：2005 - 2013年纽约州镰状细胞患者的医院入学，死亡率和合并症

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Analyses of administrative and large data sources in Sickle Cell Disease (SCD) can answer questions not suitable for prospective study but have been hampered by lack of validated methods to adjust for individual comorbidities and lack of baseline utilization data over time. We sought to develop a database to characterize inpatient SCD care across New York State and generate a re-weighted sickle-cell specific Charlson Comorbidity index (S-CCI) for use in future large data SCD research. We identified 18,541 individual SCD patients admitted to New York State hospitals between 2005 and 2013 from the SPARCS database. We present data from both a randomly selected derivation cohort, used to develop the S-CCI and a validation cohort, The S-CCI resulted in small improvements in model fit and discrimination while using fewer covariates, allowing a more parsimonious model. Despite being the most common comorbidity, chronic pulmonary disease was not predictive of mortality. Mortality per hospitalization was 0.61%. Many patients (32%) were admitted only once during the nine year period. However, the majority was admitted more frequently with over 15% of patients being admitted more than once per year.
机译：镰状细胞疾病的行政和大型数据来源（SCD）的分析可以回答不适合前瞻性研究的问题，但由于缺乏验证的方法而受到阻碍，以调整个体合并症以及随着时间的推移缺乏基线利用数据。我们试图开发一个数据库，以在纽约状态展示住院人员SCD关注，并为未来的大数据SCD研究生成重牌镰状细胞特定查理合并症指数（S-CCI）。我们确定了18,541名的个人SCD患者，从SPARCS数据库中达到了2005年至2013年的纽约州立医院。我们从用于开发S-CCI和验证队员的随机选择的推导队组织的数据，S-CCI在使用更少的协变量时，S-CCI导致模型适合和歧视的更大改善，允许更加令人愉快的模型。尽管是最常见的合并症，但慢性肺病不是预测死亡率。每张住院的死亡率为0.61％。许多患者（32％）仅在九年期间仅录取一次。然而，大多数人更频繁地承认，超过15％的患者每年不止一次。

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