...
首页> 外文期刊>Scientific reports. >In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography
【24h】

In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography

机译:使用多普勒光学相干断层扫描的淋巴速度和体积流量的无淋巴流速和体积流量的免标记测量

获取原文
           

摘要

Direct in vivo imaging of lymph flow is key to understanding lymphatic system function in normal and disease states. Optical microscopy techniques provide the resolution required for these measurements, but existing optical techniques for measuring lymph flow require complex protocols and provide limited temporal resolution. Here, we describe a Doppler optical coherence tomography platform that allows direct, label-free quantification of lymph velocity and volumetric flow rates. We overcome the challenge of very low scattering by employing a Doppler algorithm that operates on low signal-to-noise measurements. We show that this technique can measure lymph velocity at sufficiently high temporal resolution to resolve the dynamic pulsatile flow in collecting lymphatic vessels.
机译:直接体内成像淋巴流是理解正常和疾病状态下淋巴系统功能的关键。光学显微镜技术提供这些测量所需的分辨率,但用于测量淋巴流的现有光学技术需要复杂的协议并提供有限的时间分辨率。在这里,我们描述了一种多普勒光学相干断层扫描平台,其允许直接,无标记的淋巴速度定量和体积流量。我们通过采用在低信噪比测量上运行的多普勒算法来克服非常低散射的挑战。我们表明该技术可以以足够高的时间分辨率测量淋巴速度,以解决收集淋巴管中的动态脉动流。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号