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Biodegradable Optical Fiber in a Soft Optoelectronic Device for Wireless Optogenetic Applications

机译:用于无线光源应用的软光电器件中的可生物降解光纤

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Optogenetics is a new neuroscience technology that uses light-responsive proteins to stimulate neurons with light and control the emotions and/or behavior of animals. There are a few approaches to deliver light to neurons in vivo, including a using an optical fiber that can send light from an external source to a target neuron, directly inserting a light-emitting device, and shooting light to penetrate tissue from the outside. Among these methods, inserting a wireless light-emitting device that is capable of being used for an experiment while leaving an animal completely free is a method that has been studied in recent years. At the same time, the possibility of causing mechanical and thermal damage to neural tissues has been highlighted as an issue due to the stiffness of robust injection tools and the photoelectric efficiency of light-emitting diodes (LEDs). In this study, we developed a device that can send light from a wireless light-emitting device to a target neuron without mechanical and thermal effects and analyzed the optical and thermal characteristics of the device to be used for optogenetic studies.
机译:Optogenetics是一种新的神经科学技术,使用光响应蛋白刺激神经元,并控制动物的情绪和/或行为。在体内递送光到神经元的方法,包括使用可以将来自外部源的光的光纤直接插入发光器件,并射击从外部渗透组织。在这些方法中,插入能够用于实验的无线发光装置,同时完全离开动物是近年来研究的方法。同时,由于鲁棒喷射工具的刚度和发光二极管(LED)的光电效率,已经突出了导致神经组织对神经组织的机械和热损伤的可能性。在这项研究中,我们开发了一种可以将来自无线发光装置的光发送到目标神经元的装置,而无需机械和热效果,并分析了用于致光学研究的装置的光学和热特性。

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