Background: Identifying when intubated patients are ready to be extubated remains challenging. The negative inspiratory force (NIF) is a recommended predictor of weaning success. However, little is known about the role of NIF in the weaning process for the Asian surgical intensive population, especially for the Vietnamese population. Here, we aimed to investigate the cutoff threshold and predictive value of the NIF index for predicting the success of ventilator weaning in Vietnamese surgical intensive care patients. Methods: A cross-sectional study was conducted at the Surgical Intensive Care Unit of Viet Duc Hospital from October 2016 to August 2017. A total of 64 patients aged 16–70 years undergoing ventilatory support through an orotracheal tube satisfied the criteria for readiness to begin weaning. The correlation between the NIF index with outcomes of the weaning process was analyzed. Specificity (Sp), sensitivity (Se), positive predictive value (PPV), negative predictive value (NPV), receiver operating characteristic (ROC) curve, and area under the curve (AUC) were calculated. Results: The success rate of the entire weaning process was 67.2% (43/64). The median NIF values were –26.0 cm Hsub2/subO (interquartile range [IQR], –28.0 to –25.0) in the successful weaning group and –24.0 cm Hsub2/subO (IQR, –25.0 to –23.0) in the weaning failure group (P0.001). According to ROC analysis, an NIF value ≤–25 cm Hsub2/subO predicted weaning success (AUC, 0.836) with 91% Se, 62% Sp, 83% PPV, and 77% NPV. Conclusions: An NIF cutoff threshold ≤–25 cm Hsub2/subO can be used as predictor of weaning success in Vietnamese surgical intensive care patients.
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机译：背景：识别插管患者准备被拔管的情况仍然具有挑战性。负吸入力（NIF）是断奶成功的推荐预测因素。然而，关于NIF在亚洲手术密集型人口断奶过程中的作用毫无熟悉，特别是对于越南人口而言。在这里，我们旨在调查NIF指标的截止阈值和预测值，以预测越南手术密集护理患者呼吸器断奶成功的索引。方法：2016年10月至2017年8月在越南医院的手术密切护理单位进行了横截面研究。通过orotracheal管通过Orotracheal管呼吸支持的64名患者共满足准备就绪的标准断奶。分析了与断奶过程结果的NIF指标之间的相关性。特异性（SP），灵敏度（SE），阳性预测值（PPV），否定预测值（NPV），接收器操作特征（ROC）曲线和曲线下的面积（AUC）。结果：整个断奶过程的成功率为67.2％（43/64）。中位数的NIF值为-26.0 cm h 2 o（在成功的断奶组中（intquartile范围[iqr]，-28.0至-25.0），以及-24.0cm h 2 o （IQR，-25.0至-23.0）在断奶衰竭组中（P <0.001）。根据ROC分析，NIF值≤-25cm H 2 O预测断奶成功（AUC，0.836），91％SE，62％SP，83％PPV和77％NPV。结论：NIF截止阈值≤-25cm H 2 O可用作越南外科重症治疗患者断奶成功的预测因子。
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