首页>
外文期刊>Asian Pacific Journal of Cancer Prevention
>Proliferative Activity of Myoepithelial Cells in Normal Salivary Glands and Adenoid Cystic Carcinomas Based on Double Immunohistochemical Labeling
【24h】
Proliferative Activity of Myoepithelial Cells in Normal Salivary Glands and Adenoid Cystic Carcinomas Based on Double Immunohistochemical Labeling
Objective: To investigate the proliferative activity of myoepithelial cells (MEC) in normal salivary glands (NSG)and adenoid cystic carcinomas (ACC)) Study design. Twenty -three salivary gland specimens (13 ACC, 10 NSG)were studied using double immunohistochemical labeling for α smooth muscle actin (a-SMA) and proliferative cellnuclear antigen (PCNA)). Results: There was a significant difference in PCNA reactivity in normal samples betweenmyoepithelial cells of the parotid glands and of the submandibular glands, rates being higher in the latter. Neoplasticmyoepithelial cells exhibited higher expression than neoplastic epithelial cells. In addition, myoepithelial cells of thecribriform type of ACC showed PCNA reactivity lower than those of the tubular type, whereas there was no statisticallysignificant difference in epithelial cell rates. We could not identify myoepithelial cells in solid pattern due to α-SMAnegativity; although high PCNA reactivity was evident. Conclusion: These data suggest that the myoepithelial cell has akey role in ACC oncogenesis, more so than its epithelial cell counterparts. Moreover, the data provide a histopathologicalinterpretation for aggressive clinical features of submandibular ACC, as the myoepithelial cells were less differentiatedas compared to those of parotid glands.
展开▼
