Background: The tumor suppressor p53 is as a regulator of cell proliferation, apoptosis and many other biological processes as well as external and internal stress responses. Mdm2 SNIP309 is a negative regulator of 53. Therefore, this study aimed to determine the role of the Mdm2 SNIP 309 polymorphism in the gastric mucosal morphological patterns in patients with Helicobacter pylori associated gastritis. Materials and Methods: A prospective cross-sectional study was carried out from November 2014 through November 2015. Biopsy specimens were obtained from patients and infection was proven by positive histology. Gastric mucosa specimens were sent to the Molecular Genetics Unit, Institute of Medicine, Suranaree University of Technology where they were tested by molecular methods to detect the patterns of Mdm2 SNIP 309 polymorphism using the real-time PCR hybridization probe method. The results were analyzed and correlated with gastric mucosal morphological patterns by using C-NBI endoscopy. Results: A total of 300 infected patients were enrolled and gastric mucosa specimens were collected. In this study the percentage of Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous was 78% and 19 % respectively whereas Mdm2 SNIP309 G/G homozygous was 3%. Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygosity correlated with type 1 to type 3 gastric mucosal morphological patterns (P0.01) whereas Mdm2 SNIP309 G/G homozygous correlated with type 4 and type 5 (P0.01). Conclusions: Our study finds the frequency of Mdm2 SNIP309 G/G in a Thai population is very low, and suggests that this can explain ae Thailand enigma. Types 1 to type 3 are the most common gastric mucosal morphological patterns according to the unique genetic polymorphism of MDM2 SNIP 309 in the Thai population.
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机译：背景：肿瘤抑制器P53作为细胞增殖，细胞凋亡和许多其他生物过程以及外部和内应激反应的调节剂。 MDM2 Snip309是53的负调节器。因此，本研究旨在确定MDM2 Snip 309多态性在幽门螺杆菌相关胃炎患者胃粘膜形态模式中的作用。材料和方法：从2014年11月到2015年11月进行了一项前瞻性横截面研究。从患者获得活检标本，并通过阳性组织学证明感染。胃粘膜标本被送到Sulanaree工业大学的分子遗传学单位，通过分子方法检测使用实时PCR杂交探针方法检测MDM2 Snip 309多态性的模式。通过使用C-NBI内窥镜检查，分析并与胃粘膜形态模式进行分析和相关。结果：共征收300名感染患者，收集胃黏膜标本。在这项研究中，MDM2 Snip 309 T / T纯合的百分比和MDM2 SNIP309 G / T杂合子分别为78％和19％，而MDM2 SNIP309 g / g纯合纯合金为3％。 MDM2 Snip 309 T / T纯合和MDM2 SNIP309 G / T杂合性与型1型至型3型胃粘膜形态图案（P <0.01），而MDM2 SNIP309 g / g纯合与4型和5型均匀相关（P <0.01）。结论：我们的研究发现泰国人口中MDM2 Snip309 G / G的频率非常低，并表明这可以解释AE泰国谜。 1型至3型是根据泰国人群的MDM2 Snip 309的独特遗传多态性的最常见的胃粘膜形态学。
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