While Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is disrupting lives across the globe for everyone, it has a more devastating impact on the health of older adults, especially that of older men. This pandemic has highlighted the crucial importance of considering an individual’s age and biological sex in the clinic in addition to other confounding diseases (Kuchel, G.A, J Am Geriatr Soc, 67, 203, 2019, Tannenbaum, C., Nature, 575 451-458, 2009) As an interdisciplinary team of scientists in immunology, hematology, genomics, bioinformatics, and geriatrics, we have been studying how age and sex shape the human immune system. Herein we reflect on how our recent findings on the alterations of the immune system in aging might contribute to our current understanding of COVID-19 infection rate and disease risk.
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机译：虽然由严重急性呼吸综合征冠状病毒2（SARS-COV-2）引起的冠状病毒疾病2019（Covid-19），但在全球范围内扰乱了每个人的生活，对老年人的健康产生了更具破坏性的影响，特别是老年人。这种大流行突出了在其他混乱疾病（Kuchel，Ga，J Am Geriad Soc，67,203,2019，Tannenbaum，C.，Nature，575 451- 458,2009）作为免疫学，血液学，基因组学，生物信息学和老年教学的跨学科团队，我们一直在研究人类免疫系统的年龄和性别。在此，我们反思了我们最近对衰老的免疫系统改变的发现可能有助于我们目前对Covid-19感染率和疾病风险的理解。
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