In this research, carbon paste electrode (CPE) was modified with MgO/SWCNTs nanocomposite and 1-methyl-3-octylimidazolium tetrafluoroborate (MOCITFB) and then used as a highly sensitive analyticalapproach for the determination of morphine in drug samples. In this study, the MgO/SWCNTs wassynthesized using the simple precipitation method. The TEM image displayed the decoration of MgOnanoparticles with diameter ? 40 nm at surface of SWCNTs. In addition, the electrochemical behaviorof morphine was also investigated at surface of MgO/SWCNTs/MOCITFB/CPE with different pHvalues. The findings displayed an electro-oxidation mechanism in the presence of one electron and oneproton. Moreover, the oxidation signal of morphine showed a linear calibration curve in theconcentration range of 3.0 nM to 320 μM with the detection limit pf 0.8 nM at surface ofMgO/SWCNTs/MOCITFB/CPE. Moreover, the MgO/SWCNTs/MOCITFB/CPE was successfully usedfor the determination of morphine in injection sample with recovery range of 98.41% to 102.49%.
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