Present study aims to use Go/Fe3O4/SiO2 nanocomposite modified screen printed electrode forelectrochemical determination of clozapine. To that end, scanning electron microscopy (SEM)technique was used to study the surface morphology of the Go/Fe3O4/SiO2 nanocomposite. Thefindings of the study showed that modified electrode has an excellent electrocatalytic performancetoward oxidation of clozapine. A linear increase in differential pulse voltammetric peaks current ofclozapine was observed with their concentrations in the range of 0.1-700.0 μM. The detection limitobtained for clozapine was 0.03 μM. Some advantages of using proposed sensor, among the others,were fast response time, high sensitivity, signal stability, low cost, ease of preparation and the lack of need for using any specific electron-transfer mediator or specific reagent. Accordingly, modifiedelectrode can be used without any need for separation or pretreatment steps to detect clozapine in realsamples.
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