This paper verified the biosensors of molybdenum disulfide (2) and the colloidal gold probe toamplify signals studied by using quartz crystal microbalance (QCM) sensor. The chemical reaction wasresulted in the formation of colloidal gold probes by immune colloidal gold technique and then verifiedby double antibody sandwich techniques (ELISA). Nanometer 2 as the sensitive material of sensorwas produced by hydrothermal method. The scanning electron microscope (SEM) and transmissionelectron microscope (TEM) electron microscopy showed that the gold nanoparticles were successfullymodified on anti-CA15-3 antibodies and the prepared 2 was typical two-dimensional material witha hexagonal sheet structure. We found that these QCM sensors had high sensitivity (26. 303 ±1.139/, 1/) and good linearity (0.960 ± 0.013) within the concentration range of CA15-3 between 0.5/ and 100/. The results show that the response time of the system was less than20, had reproducibility and selectivity. It indicated that nanometer 2 is a good biosensor material.
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