Background: Lead (Pb) is one of the most common environmental toxicants, exposure to which can cause significant neurotoxicity and an associated decline in brain function. Plant derived products with antioxidants activity are useful in reducing lead induced neurotoxicity. This study investigated neuroprotective and antioxidant properties of the aqueous Xylopia aethiopica against lead -induced neurotoxicity in male Wistar rats. Methods: Six groups of six weight-matched animals each, were used for the study. The group 1 (normal control) was treated with distilled water and group 2 (toxic control) with lead acetate at the doses of 50 mg/kg b.wt, whereas group 3 received only Xylopia aethiopica 40 mg/kg only, groups 4, 5, and 6 were simultaneously treated with lead (50 mg/kg b.w.), and 40mg/kg, 80mg/kg, and 160mg/kg of Xylopia aethiopica respectively The treatment was administered orally for 42 days. Their biochemical and histopathological investigations were carried out following animal sacrifice at the end of the study period. The neuroprotective effect of Xylopia aethiopica was assessed by measuring redox status (malondialdehyde), enzymatic antioxidant activities (Superoxide dismutase, Catalase, Glutathione peroxidase and glutathione reductase) and histopathology of the cerebral cortex. Results: The increase in the malondialdehyde, the decrease in the activity of antioxidant enzymes (Catalase, Glutathione peroxidase and reductase), and the altered histology of the brain induced neurotoxicity by lead acetate were mitigated in the brain of rats treated with Xylopia aethiopica. Conclusion: Aqueous Xylopia aethiopica has a neuroprotective role against lead - induced neurotoxicity probably mediated through its antioxidant properties.
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机译：背景：铅（Pb）是最常见的环境毒性之一，暴露可能导致显着的神经毒性和脑功能相关的下降。具有抗氧化剂活性的植物衍生产品可用于降低铅诱导的神经毒性。本研究研究了含含含含量的含水木偶亚硝酸的神经保护和抗氧化特性，免受雄性Wistar大鼠铅诱导的神经毒性。方法：各种六组六组六组，用于研究。第1组（正常对照）用蒸馏水和第2组（毒性对照）用乙酸铅处理，乙酸剂量为50mg / kg B.wt，而第3组仅接受Xaleapia Aethiopica 40mg / kg，第4组，用铅（50mg / kg bw）同时处理5和6，分别将治疗施用40mg / kg，80mg / kg和160mg / kg Xexhiopica，将治疗施用42天。在研究期结束时，在动物牺牲后进行了生化和组织病理学研究。通过测量氧化还原状态（丙二醛），酶促抗氧化活性（超氧化物歧化酶，过氧化物酶，谷胱甘肽过氧化物酶，谷胱甘肽过氧化物酶）和脑皮质组织病理学来评估Xalepia Aethiopica的神经保护作用。结果：丙二醛的增加，抗氧化酶活性（过氧化氢酶，谷胱甘肽过氧化物酶和还原酶）的减少，以及通过乙酰丙酸盐的大鼠脑进行脑肿瘤诱导神经毒性的改变组织学。结论：含含水的含水性艾甲酸钠对铅诱导的神经毒性可能通过其抗氧化性能介导的铅诱导的神经毒性作用。
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