With nearly 100 million people affected in the United States with nonalcoholic fatty liver disease (NAFLD) and projections for the advanced stages of NAFLD to soon become the leading indication for liver transplantation, nonalcoholic steatohepatitis (NASH) remains a significant area of unmet medical need. Therapeutic options for NASH are a critical priority for clinicians, drug developers and regulatory authorities. The epidemic proportions have led to a surge in the development of novel drugs aimed at the complex pathogenesis of NASH and in regulatory submissions. There are currently no approved drugs in the United States for the treatment of adult or paediatric NASH. Potential therapeutic targets include steatosis, glucose metabolism, lipogenesis, oxidative stress, apoptosis, fibrosis and immunomodulation, all intended to alter the pathophysiology of NASH and remedy its associated complications.
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