OBJECTIVE Endoscopic pituitary surgery (EPS) via the endonasal transsphenoidal approach is well established as an effective treatment modality for sellar masses. The objective of this study was to determine the relationship between key patient and operative variables and rhinological outcomes as determined by the 22-item Sino-Nasal Outcome Test (SNOT-22) and endoscopic scores following EPS. METHODS Prospectively collected SNOT-22 scores and objective endoscopic data were analyzed from a cohort of 109 patients who underwent EPS and had at least 90 days of postoperative follow-up. Trends in postoperative SNOT-22 scores were analyzed using linear mixed-effects models. Time to return to baseline endoscopic score was analyzed using Cox regression. RESULTS After adjusting for age and sex, the authors found that prior smokers had higher total and rhinological subdomain SNOT-22 scores (p 0.01, 95% CI 5.82–16.39; p = 0.01, 95% CI 1.38–5.09, respectively) following EPS. Nasoseptal flap use also showed higher total and rhinological subdomain SNOT-22 scores (p = 0.01, 95% CI 1.62–12.60; p = 0.02, 95% CI 0.42–4.30, respectively). Prior sinonasal surgery and concurrent septoplasty did not affect the change in SNOT-22 total scores over time (p = 0.08, 95% CI ?0.40 to 0.02; p = 0.33, 95% CI ?0.09 to 0.29). CONCLUSIONS The findings suggest that the evolution of healing and patient-reported quality of life (QOL) measures are multifaceted with contributions from two key variables. Nasoseptal flap usage and prior smoking status may adversely impact postoperative QOL. No variables were found to be associated with objective postoperative endoscopic findings.
展开▼
机译：目的通过内切形晶状体方法（EPS）通过内切态胸腔方法，是塞拉克萨斯群众的有效治疗方式。本研究的目的是确定关键患者和手术变量之间的关系，以及由EPS之后的22项中鼻结果测试（SNOT-22）和内窥镜评分确定的泌尿过程结果。方法从接受EPS的109名患者的群组中分析了鼻22分和目的内窥镜数据，并在术后至少90天的术后随访中分析了。使用线性混合效应模型分析术后鼻涕-22分数的趋势。使用COX回归分析了返回基线内窥镜评分的时间。结果在调整年龄和性别后，作者发现，患者的总量较高，鼻咽亚剧集-22分数更高（P <0.01,95％CI 5.82-16.39; P = 0.01,95％CI 1.38-5.09）以下eps。鼻孔皮瓣使用也显示出更高的总和和鼻域鼻塞-22分数（P = 0.01,95％CI 1.62-12.60; p = 0.02,95％CI 0.42-4.30）。先前的Sinonasal手术和同时的emporporatacty不会影响鼻涕-22的变化，随着时间的推移，P = 0.08,95％CI？0.40至0.02; p = 0.33,95％CI？0.09至0.29）。结论研究结果表明，愈合和患者报告的寿命质量（QOL）措施的演变是多方面的两个关键变量的贡献。鼻孔皮瓣用法和射击状态可能会对术后QOL产生不利影响。没有发现任何变量与客观的术后内窥镜检查结果相关。
展开▼
