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外文期刊>Orthopaedic Journal of Sports Medicine
>Hyperlipidemia Is a Risk Factor of Adhesive Capsulitis: Real-World Evidence Using the Taiwanese National Health Insurance Research Database
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Hyperlipidemia Is a Risk Factor of Adhesive Capsulitis: Real-World Evidence Using the Taiwanese National Health Insurance Research Database
Background: Patients with adhesive capsulitis are evaluated for pain and progressive contracture of the glenohumeral joint. Whether endocrine, immune, or inflammatory processes are involved in its definite pathogenesis is still under debate. Some cross-sectional studies with a small sample size have noted that hyperlipidemia is a possible risk factor for frozen shoulders. Purpose/Hypothesis: The purpose was to conduct a longitudinal population-based study to investigate the risk of adhesive capsulitis among patients with hyperlipidemia. It was hypothesized that patients with hyperlipidemia would have a higher risk of adhesive capsulitis and that the use of statin drugs could reduce the rate. Study Design: Cohort study; Level of evidence, 3. Methods: Using data from the National Health Insurance Research Database (NHIRD) of Taiwan, the authors obtained the records of patients with hyperlipidemia who received a diagnosis between 2004 and 2005 and were followed up until the end of 2010. The control cohort comprised age- and sex-matched patients without hyperlipidemia. Propensity score matching was performed for the other comorbidities. A Cox multivariate proportional hazards model was applied to analyze the risk factors of adhesive capsulitis. The hazard ratio (HR) and adjusted HR were estimated between the study and control cohorts after adjustment for confounders. The effects of statin use on adhesive capsulitis risk were also analyzed. Results: The NHIRD records of 28,748 patients and 114,992 propensity score–matched controls were evaluated. A higher incidence rate of adhesive capsulitis was revealed in the hyperlipidemia cohort, with a crude HR of 1.70 (95% CI, 1.61-1.79; P & .001) and adjusted HR of 1.50 (95% CI, 1.41-1.59; P & .001). Patients with hyperlipidemia who used a statin still had higher crude and adjusted HRs compared with controls. Statin use did not exert protective effects on patients with hyperlipidemia. Conclusion: Patients with hyperlipidemia had a 1.5-fold higher risk of adhesive capsulitis than did healthy controls. Statin use did not provide protection against adhesive capsulitis in patients with hyperlipidemia.
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机译：背景：粘性胶囊炎的患者是针对Glenohumern关节的疼痛和渐进挛缩的患者。内分泌，免疫或炎症过程是否涉及其确定的发病机制仍在辩论中。具有小样本大小的一些横截面研究已经注意到，高脂血症是冷冻肩部的可能危险因素。目的/假设：目的是进行纵向群体的研究，以探讨高脂血症患者粘性囊炎的风险。假设高脂血症的患者具有更高的粘性胶囊炎的风险，并且使用他汀类药物的使用可以降低速率。研究设计：队列研究;方法：方法：使用台湾国民健康保险研究数据库（纳希尔）的数据，作者获得了高脂血症患者的记录，他们在2004年至2005年期间接受了诊断，并随访截至2010年底。该控制队列包括没有高脂血症的年龄和性匹配的患者。对其他合并症进行倾向得分匹配。应用COX多变量比例危害模型分析胶囊毛细管炎的危险因素。危险比（HR）和调整后的人力资源在对混凝器调整后的研究和对照队列之间估算。还分析了他汀类药物对粘性胶囊炎风险的影响。结果：评估患者28,748名患者和114,992名倾向匹配对照的纳米尔记录。高脂血症队列中揭示了粘合剂胶囊炎的发病率较高，粗产值为1.70（95％CI，1.61-1.79; P＆ 0.001），调整为1.50（95％CI，1.41-1.59; P. ＆ .001）。与对照组相比，使用他汀类药物的高脂血症患者仍然具有更高的原油和调整后的HRS。他汀类药物对高脂血症患者没有发挥保护作用。结论：高脂血症患者的粘性胶囊炎的风险高1.5倍，比健康对照对抗。他汀类药物用途没有提供患有高脂血症患者的粘合囊炎的保护。
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