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>The effect of carnosine or β-alanine supplementation on markers of glycaemic control and insulin resistance in human and animal studies: a protocol for a systematic review and meta-analysis
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The effect of carnosine or β-alanine supplementation on markers of glycaemic control and insulin resistance in human and animal studies: a protocol for a systematic review and meta-analysis
Diabetes is a major public health issue and there is a need to develop low-cost, novel interventions to prevent or reduce disease progression. Growing evidence shows that supplementation with carnosine, or its rate-limiting precursor β-alanine, can ameliorate aspects of the metabolic dysregulation that occurs in diabetes. There is, however, a need to develop a better understanding of the magnitude of effect and the factors associated with positive outcomes. The purpose of this systematic review and meta-analysis is to evaluate the effect of carnosine or β-alanine supplementation on markers of glycaemic control and insulin resistance in humans and animals. We will perform a systematic search for randomised and non-randomised controlled trials. Studies will be retrieved by searching electronic databases, clinical trial registers, author review, and cross-referencing. Primary outcomes include changes in (i) fasting glucose, (ii) glycated haemoglobin, and (iii) 2-h glucose following a glucose tolerance test. A set of additional outcomes includes other markers of glycaemic control and insulin resistance. Risk of bias (RoB) will be assessed using the Cochrane RoB 2.0 tool (human studies) and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) RoB tool (animal studies). Confidence in the cumulative evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. All meta-analyses will be conducted within a Bayesian framework, providing a flexible modelling approach to account for uncertainty in model parameters and underlying structures within the data. By including all available human and animal data, we will provide the most comprehensive overview on the topic to date. The results will have implications for those working in prediabetes, diabetes, and metabolic health in general and may lead to the development of new treatment approaches. Study results will be presented at a professional conference and published in a peer-reviewed journal. CRD42020191588
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机译：糖尿病是一个主要的公共卫生问题，需要开发低成本，以预防或减少疾病进展的低成本，新的干预措施。日益增长的证据表明，用肉毒苷或其速率限制前体β-丙氨酸的补充可以改善在糖尿病中发生的代谢性失衡的方面。然而，需要更好地了解对效果的程度和与阳性结果相关的因素。该系统审查和荟萃分析的目的是评估肉毒苷或β-丙氨酸补充对人与动物血糖控制和胰岛素抗性标志物的影响。我们将对随机和非随机对照试验进行系统搜索。通过搜索电子数据库，临床试验登记，作者审查和交叉引用，将检索研究。主要结果包括（i）空腹葡萄糖，（ii）糖化血红蛋白的变化和（iii）2-H葡萄糖在葡萄糖耐受试验之后。一组额外的结果包括血糖控制和胰岛素抵抗的其他标志物。将使用Cochrane Rob 2.0工具（人类研究）和实验室动物实验（Syrcle）Rob工具（动物研究）进行评估偏差（ROB）的风险。利用建议评估，开发和评估（等级）方法的评分评估对累积证据的信心。所有META分析将在贝叶斯框架内进行，提供灵活的建模方法，以解释模型参数和数据底层结构中的不确定性。通过包括所有可用的人类和动物数据，我们将提供最全面的概述迄今为止。结果将对普通期，糖尿病和代谢健康工作的人产生影响，可能导致新的治疗方法的发展。研究结果将在专业会议上颁发并在同行评审期刊上发表。 CRD42020191588
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