Reproduction, fat metabolism, and longevity are intertwined regulatory axes; recent studies in C. elegans have provided evidence that these processes are directly coupled. However, the mechanisms by which they are coupled and the reproductive signals modulating fat metabolism and lifespan are poorly understood. Here, we find that an oogenesis-enriched gene, c30f12.4 , is specifically expressed and located in germ cells and early embryos; when the gene is knocked out, oogenesis is disrupted and brood size is decreased. In addition to the reproductive phenotype, we find that the loss of c30f12.4 alters fat metabolism, resulting in decreased fat storage and smaller lipid droplets. Meanwhile, c30f12.4 mutant worms display a shortened lifespan. Our results highlight an important role for c30f12.4 in regulating reproduction, fat homeostasis, and aging in C. elegans , which helps us to better understand the relationship between these processes.
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机译：再现，脂肪代谢和寿命是交织的调节轴; C. C.埃贝朗斯的最近研究提供了证据表明这些过程直接耦合。然而，它们耦合的机制和调节脂肪代谢和寿命的生殖信号很差。在此，我们发现富含富集的基因C30F12.4，特异性地表达并位于生殖细胞和早期胚胎中;当基因被淘汰时，造成的ofercis被破坏并衡量尺寸减小。除了生殖表型外，我们发现C30F12.4的损失改变了脂肪代谢，导致脂肪储存减少和较小的脂质液滴。同时，C30F12.4突变蠕虫显示缩短的寿命。我们的结果突出了C30F12.4在C30F12.4在C.秀丽隐杆线上的繁殖，脂肪稳态和老化方面的重要作用，这有助于我们更好地了解这些过程之间的关系。
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