Purpose: To evaluate whether high vs low-dose steroids or non-steroid improve the clearance rates of jaundice, cholangitis, and survival rates with the native liver in biliary atresia (BA) after Kasai portoenterostomy. Methods: Potential prospective and retrospective controlled trials were extracted from the computer database. Odds ratios (OR) with 95% confidence intervals (CI) were calculated for the clearance rates of jaundice, cholangitis and survival rates with native liver. Findings: The pooled OR significantly favour high-dose steroids (the cumulative dosage of prednisolone over 80 mg/kg) over low-dose steroids (the cumulative dosage of prednisolone less than 43 mg/kg) (1.804; 95%CI: 1.286, 2.531; P=0.001) or non-steroid (2.236; 95% CI: 1.122, 4.458; P=0.022) in the clearance rates of jaundice. Conclusion: High-dose steroids in postoperative BA improve the clearance rates of jaundice compared with low-dose steroids and non-steroid at a follow up of 6 months.
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机译：目的：评估高与低剂量类固醇或非类固醇是否提高黄疸，胆管炎和在Kasai PortoentoRostomy之后与胆道Atresia（BA）的天然肝脏的清除率。方法：从计算机数据库中提取潜在的前瞻性和回顾性控制试验。对于95％置信区间（CI）的差异比率（或）计算黄疸，胆管炎和生物肝脏存活率的清除率。结果：汇集或显着涉及低剂量类固醇的高剂量类固醇（泼尼松龙超过80毫克/千克的累积剂量）（泼尼松龙的累积剂量小于43 mg / kg）（1.804; 95％CI：1.286， 2.531; p = 0.001）或非类固醇（2.236; 95％CI：1.122,4.458; p = 0.022），是黄疸的清除率。结论：术后BA的高剂量类固醇提高了黄疸的清除率与低剂量类固醇和非类固醇，在6个月的后续后。
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