A case of hydroa vacciniforme-like Epstein-Barr virus-associated lymphoproliferative disease (LPD) in a 9-year-old boy is reported in this paper. The patient had recurrent fever for 3 months accompanied by skin lesions. Immunohistochemistry of a skin biopsy revealed that the lymphocytes were positive for T cell markers. Flow cytometric analysis of peripheral blood showed a significantly increased percentage of natural killer cells and 91% CD158i monoclonal expression. The conclusion of the skin histopathology was EBV-positive cutaneous LPD. Laboratory tests on peripheral blood and immunohistochemistry of the skin biopsy confirmed that the child was infected with Epstein-Barr virus. Note: CD158i (Official Full Name: killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4).
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