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>Data on the relationship of signal-to-cutoff ratio of two HIV antigen/antibody combination assays to subsequent confirmation of HIV-1 infection in a low-prevalence population
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Data on the relationship of signal-to-cutoff ratio of two HIV antigen/antibody combination assays to subsequent confirmation of HIV-1 infection in a low-prevalence population
HIV-1/2 antigen/antibody (Ag/Ab) immunoassays that detect HIV-1 and HIV-2 antibodies and HIV-1 p24 antigen are commonly used in the diagnosis of HIV-1/HIV-2 infections in human plasma/serum. Samples from patients with positive screening results require confirmation by antibody differentiation and/or HIV PCR assays. HIV screening assays are commonly reported as positive or negative based on a signal-to-cutoff (S/CO) threshold. For some HIV screening assays, the strength of the S/CO value correlates with likelihood that confirmatory testing will be positive. The data in this article provide results from two HIV Ag/Ab combination assays (Abbott Architect HIV Ag/Ab Combo Assay, a 4thgeneration combination assay; Bio-Rad Bioplex 2200 HIV Ag-Ab Assay, a 5thgeneration assay). The data include 23,331 HIV screening results, S/CO ratios, antibody differentiation or Western blot results (for samples with positive HIV screens), HIV-1 PCR results (if performed), patient location at time of testing, age, and sex. Distribution of S/CO ratios for the Bio-Rad HIV screening assay data and the distribution of S/CO values for samples with positive screening results were analyzed.
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机译：检测HIV-1和HIV-2抗体和HIV-1P24抗原的HIV-1/2抗原/抗体（AG / AB）免疫测定通常用于人血浆/血清中HIV-1 / HIV-2感染的诊断。来自阳性筛选结果的患者的样品需要通过抗体分化和/或HIV PCR测定确认。基于信号到截止（S / CO）阈值，通常报告HIV筛选测定通常是正面的或阴性。对于一些HIV筛查测定，S / CO值的强度与确认测试是阳性的可能性相关。本文中的数据提供了来自两个HIV AG / AB组合测定的结果（Abbott Architect HIV Ag / Ab组合测定，4个组合组合测定; Bio-rad Bioplex 2200 HIV Ag-Ab测定，5个变量测定）。数据包括23,331艾滋病毒筛查结果，S / Co比率，抗体分化或蛋白质印迹结果（用于阳性艾滋病毒筛选的样品），HIV-1 PCR结果（如果进行），在测试时，患者的位置，年龄和性别。分析了Bio-rad HIV筛选测定数据的S / CO比的分布和S / CO值的分布，样品具有阳性筛选结果。
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